Year of writing:1924 Reading time:Description of the work:The novel The White Guard, ...
in orange glass bottles of 100 g; in a box 1 bottle (a measure with a scale is attached to the package).
Description of the dosage form
Suspension orange color with an orange smell and sweet taste, with a slightly perceptible burning aftertaste. There may be a separation into a liquid layer and a precipitate, which, after mixing, constitute a homogeneous suspension.
pharmachologic effect
Antipyretic, analgesic, anti-inflammatory. It blocks arachidonic acid cyclooxygenase and reduces the synthesis of PG. The antipyretic result is due to a decrease in the concentration of PG in the cerebrospinal fluid, a decrease in the excitation of the thermoregulation center, the result of which is the normalization of body temperature. The analgesic effect is associated with a decrease in the production of PG classes E, F, I, biogenic amines, a change in the sensitivity of nociceptors and the prevention of the development of hyperalgesia. The analgesic effect is most pronounced with inflammatory pain. The anti-inflammatory result is due to a decrease in the secretion of inflammatory mediators and a decrease in the activity of the exudative and proliferative phases of the inflammatory process. The antipyretic and analgesic effect is expressed earlier and at lower doses than the anti-inflammatory effect that occurs on the 5-7th day of treatment.
Pharmacokinetics
After oral administration, more than 80% is absorbed from the gastrointestinal tract. Cmax in plasma is achieved when taken before meals - after 45 minutes, when taken after meals after 1.5-2.5 hours. Protein binding - 90%. It slowly penetrates into the joint cavity, however, in the synovial fluid it creates concentrations greater than in the blood plasma (Cmax in the synovial fluid is reached after 2-3 hours). It is metabolized usually in the liver. It undergoes pre- and post-systemic metabolism. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into active S-shape. Excreted by the kidneys (60-90% in the form of metabolites and products of their combination with glucuronic acid, to a lesser extent - with bile, unchanged - no more than 1%). It has a two-phase elimination kinetics with T1 / 2 2-2.5 hours, after administration in a single dose it is completely eliminated within 24 hours. The antipyretic effect of Ibufen develops after 30 minutes and lasts 6-8 hours.
Indications for Ibufen
As an antipyretic: with colds, acute respiratory viral infections, influenza, tonsillitis (pharyngitis), childhood infections accompanied by fever, post-vaccination reactions.
As a pain reliever: with toothache, painful teething, headache, migraine, neuralgia, pain in muscles, joints, injuries and burns.
Contraindications
Hypersensitivity (including to acetylsalicylic acid or other NSAIDs), peptic ulcer of the stomach and duodenum, severe insufficiency of the liver, kidneys, of cardio-vascular system, arterial hypertension, hemophilia, hypocoagulation, hemorrhagic diathesis, deficiency of glucose? 6-phosphate dehydrogenase, bronchospastic reactions after the use of acetylsalicylic acid or other NSAIDs ("aspirin asthma"), Quincke's edema, nasal polyps, hearing loss, infancy (up to 6 months, with body weight - below 7 kg).
Side effects
From the side of the central nervous system: headache, dizziness, sleep disturbance, anxiety, drowsiness, depression, agitation, visual impairment (reversible toxic amblyopia, blurred vision or double vision).
From the side of the hematopoietic organs: heart failure, tachycardia, increased blood pressure; anemia, thrombocytopenia, agranulocytosis, leukopenia.
From the digestive tract: nausea, vomiting, loss of appetite, heartburn, abdominal pain, diarrhea, constipation, flatulence, abnormal liver function, peptic ulcers, gastric bleeding.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: itching, rash, bronchospastic syndrome, allergic rhinitis, angioedema, Steven-Johnson syndrome, Lyell's syndrome.
Interaction
It should not be combined with other NSAIDs (acetylsalicylic acid reduces the anti-inflammatory effect and increases side effects). When taken simultaneously with diuretics, the diuretic effect decreases and the risk of developing renal failure increases. Weakens the impact antihypertensive drugs including ACE inhibitors (simultaneously reduces their excretion by the kidneys), beta-adrenergic agents, thiazides. Enhances the effect of oral hypoglycemic agents (especially sulfonylurea derivatives) and insulin, indirect anticoagulants, antiplatelet agents, fibrinolytics (increases the risk of hemorrhagic complications), the toxic effects of methotrexate and lithium preparations, increases the concentration of digoxin in the blood.
Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) increase the risk of developing severe hepatotoxic complications (increase the production of hydroxylated active metabolites), inhibitors of microsomal oxidation decrease. Caffeine enhances pain relief.
Dosage and administration
inside, after meal. The average single dosage is 5–10 mg/kg of body weight 3–4 times a day. Children aged 6 months - 1 year (7-9 kg)- 2.5 ml (50 mg) 3 times a day, the highest daily dosage is 7.5 ml (150 mg). 1–3 years (10–15 kg)- 2.5 ml (50 mg) 3-4 times a day, the largest daily dosage is 7.5-10 ml (150-200 mg). 3–6 years (16–20 kg)- 5 ml (100 mg) 3 times a day, the largest daily dosage is 15 ml (300 mg). 6–9 years old (21–30 kg)- 5 ml (100 mg) 4 times a day, the largest daily dosage is 20 ml (400 mg). 9–12 years old (31–41 kg)- 10 ml (200 mg) 3 times a day, the largest daily dosage is 30 ml (600 mg). Over 12 years old (more than 41 kg)- 10 ml (200 mg) 4 times a day, the highest daily dosage is 40 ml (800 mg). The dose may be repeated every 6-8 hours. Do not exceed the maximum daily dosage. For children from 6 months to 1 year, the drug is prescribed on the recommendation of a doctor.
Overdose
Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, hemorrhagic diathesis, decreased blood pressure, acute renal failure, abnormal liver function, tachycardia, bradycardia, atrial fibrillation; convulsions, apnea and coma (especially characteristic of children under 5 years of age).
Treatment: gastric lavage, appointment activated carbon, alkaline drinking, symptomatic therapy (correction of acid-base balance, blood pressure).
Precautionary measures
Caution should be taken with cirrhosis of the liver with portal hypertension, liver and / or kidney failure, heart failure, nephrotic syndrome, hyperbilirubinemia, peptic ulcer of the stomach and duodenum (in history), gastritis, enteritis, colitis, blood diseases (leukopenia, anemia) , pregnancy (II-III trimesters), during breastfeeding. In patients with bronchial asthma or other diseases that occur with bronchospasm, an increased risk of developing bronchospasm is likely.
During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated (conducting esophagogastroduodenoscopy, a blood test with the determination of hemoglobin, hematocrit, fecal occult blood analysis).
In the absence of an antipyretic effect for 2 days and an analgesic effect for 3 days, you should consult a doctor. In case of side effects, stop taking the medicine and consult a doctor.
special instructions
Shake the bottle before use until a homogeneous suspension is obtained. With prolonged use, NSAIDs can cause damage to the gastric mucosa, peptic ulcers, and gastrointestinal bleeding.
Sick diabetes take with caution - contains sugar.
In case of side effects, stop taking the medicine and consult a doctor.
Storage conditions of the drug Ibufen
In a dry, dark place, at a temperature of 15–25 °C.
Keep out of the reach of children.
Ibufen expiration date
Do not use after the expiry date stated on the package.
susp. d / ingestion 100 mg / 5 ml: vial. 120 ml per set with dosing spoon or dosing syringeReg. No: RK-LS-5-No. 015569 dated February 25, 2015 - Current
Suspension for oral administration white or almost white, with an orange smell.
Excipients: macrogol glycerylhydroxystearate, xanthan gum, glycerol, sodium benzoate, citric acid monohydrate, sodium phosphate dihydrate or sodium phosphate dodecahydrate, sodium saccharinate, liquid maltitol, orange flavor, purified water.
120 ml - glass bottles (1) complete with a dosing spoon - cardboard boxes.
120 ml - plastic bottles (1) complete with a dosing syringe - cardboard boxes.
Description medicinal product IBUFEN D based on officially approved instructions for use of the drug and made in 2012. Date of update: 12/28/2011
NSAIDs, a derivative of propionic acid. It has antipyretic, analgesic and anti-inflammatory effects.
The mechanism of action of ibuprofen is primarily due to the suppression of prostaglandin biosynthesis by reducing the activity of cyclooxygenase (COX), an enzyme that regulates the conversion of arachidonic acid into prostaglandins, prostacyclin and thromboxane. At the same time, as a result of irreversible inhibition of the cyclooxygenase pathway of arachidonic acid metabolism, the formation of prostaglandins decreases. A decrease in the concentration of prostaglandins at the site of inflammation is accompanied by a decrease in the formation of bradykinin, endogenous pyrogens, other biologically active substances, oxygen radicals and NO. All this leads to a decrease in the activity of the inflammatory process (anti-inflammatory effect of ibuprofen) and is accompanied by a decrease in pain reception (analgesic effect).
A decrease in the concentration of prostaglandins in the cerebrospinal fluid leads to the normalization of body temperature (antipyretic effect). The decrease in temperature begins 30 minutes after ingestion, its maximum effect is manifested after 3 hours.
The use of Ibufen D suspension helps to reduce the manifestations of symptoms such as fever, pain and swelling, by acting at the site of their occurrence.
Suction
After oral administration, more than 80% of ibuprofen is absorbed from the gastrointestinal tract, reaching Cmax in blood plasma after 1 hour. Eating slows down the absorption of ibuprofen, but does not reduce its bioavailability. The time to reach C max when taken with food is 30-60 minutes longer than when taken on an empty stomach and is 1.5-3 hours.
When taking ibuprofen in the form of a suspension in children at a dose of 10 mg / kg, its Cmax is 55 μg / ml.
Distribution
Ibuprofen binds to plasma proteins (mainly albumin) by more than 99%. A high degree of protein binding limits the rate of penetration of ibuprofen into the synovial and cerebrospinal fluid.
V d of ibuprofen in adults is about 0.12 l / kg of body weight, but in children with fever under 11 years of age, V d is about 0.2 l / kg of body weight.
Ibuprofen slowly penetrates the synovial fluid, keeping it long time therapeutic concentration. Does not accumulate in the body.
Metabolism
Ibuprofen is biotransformed mainly in the liver.
breeding
70-90% of the dose taken is excreted in the urine in the form of metabolites and products of their conjugation with glucuronic acid. The remainder of the dose is excreted in the feces unchanged and also in the form of metabolites. T 1/2 - 2-2.5 hours
The drug is taken orally after meals, with plenty of water. Before use, the vial should be shaken until a homogeneous suspension is obtained. For accurate dosing of the suspension, a dispenser (spoon or syringe) is attached to the vial.
The dose is set depending on the age and body weight of the child. When calculating the dose, it should be taken into account that 5 ml of the suspension contains 100 mg of ibuprofen.
A single dose of Ibufen D is 5-10 mg/kg of the child's body weight 3-4 times/day. The maximum daily dose of the suspension is 20-30 mg/kg of body weight, not more. The drug is prescribed in single doses according to the scheme given in the table below:
Taking the drug in a single dose can be repeated every 6-8 hours with an interval of at least 4 hours between doses in the next dose.
Children up to 6 months you can use the drug after consulting a doctor in accordance with his recommendations. Do not exceed the recommended dose.
At post-vaccination reactions in children from 3 to 6 months the dosage regimen of the drug is determined by the doctor.
Duration of treatment - no more than 3 days as an antipyretic, no more than 5 days - as an anesthetic.
If the fever persists for more than 3 days, a doctor should be consulted.
Instructions for use dispenser in the form of a syringe
1. Unscrew the cap from the vial (press downwards and turn counterclockwise).
2. Press the dispenser firmly into the opening of the bottle neck.
3. Shake the vial vigorously.
4. To fill the dispenser, the bottle must be turned upside down, and then carefully move the dispenser piston down, pour the contents until the desired mark on the scale is reached.
5. Turn the bottle upside down and remove the dispenser from it by carefully unscrewing it.
6. Place the tip of the dispenser in the child's mouth, and then, slowly pressing the piston, introduce the contents of the dispenser.
7. After use, the bottle should be closed by screwing the cap, and the dispenser should be rinsed with water and dried.
The drug is generally well tolerated.
From the digestive system: feeling of discomfort in the stomach, nausea, vomiting, abdominal pain, loss of appetite;
Allergic reactions: rarely - nonspecific allergic and anaphylactic reactions, urticaria, vasomotor edema.
Dermatological reactions: rarely - rash, itching, purpura;
From the side respiratory system: rarely - bronchospasm or suffocation, exacerbation of bronchial asthma.
From the hematopoietic system: rarely - thrombocytopenia, anemia, leukopenia.
From the side nervous system: rarely - headaches, dizziness, insomnia, excitability, irritability, drowsiness, depression, tinnitus.
- manifestations of ever earlier symptoms of allergy in the form of rhinitis, skin rashes or bronchospastic reactions after the use of acetylsalicylic acid or other NSAIDs;
- peptic ulcer of the stomach and duodenum in the acute phase, ulcerative colitis, Crohn's disease;
- the expressed insufficiency of function of a liver;
- the expressed insufficiency of function of kidneys;
- blood diseases: hemophilia, hypocoagulation, hemorrhagic diathesis;
- III trimester of pregnancy;
- children's age up to 3 months;
- hypersensitivity to ibuprofen or other NSAIDs, as well as to the auxiliary components of the drug.
Use during pregnancy and lactation
The use of ibuprofen in the I and II trimesters of pregnancy requires caution and is possible only on prescription, after assessing the expected benefits and possible risks. Do not use ibuprofen in the third trimester of pregnancy.
Ibuprofen can be excreted in small amounts from breast milk. No cases known side effects in infants, however, it is recommended to discontinue breast-feeding during treatment with ibuprofen.
When any side effects you should stop using the drug and inform your doctor about it.
The expected benefits and possible risks should be assessed before prescribing Ibufen D to a child if the child is aged 3 to 6 months.
Before taking Ibufen D, you should consult your doctor if you have a history of bronchial asthma, urticaria, liver and kidney disease, peptic ulcer of the stomach and duodenum.
The drug does not contain sugar, so it can be used in patients with diabetes.
The drug does not contain dyes and can be used in children prone to allergic reactions to dyes at recommended doses.
Special care should be taken when using the drug in patients with hereditary fructose intolerance.
The instruction brings to the attention of the patient all the information on the use of the children's drug Ibufen in medicinal purposes, and also warns against undesirable consequences in the form of overdose and side effects.
Form, composition, packaging
The drug is produced in the form of a suspension, which is taken orally. The color of the preparation is orange. The smell of orange. During storage, it is permissible to separate the liquid into liquid and sedimentary parts, which can be easily eliminated by shaking the vial.
The required amount of ibuprofen in the preparation serves as its active ingredient, the rest is auxiliary substances. The additional complex includes the calculated proportions of carmellose sodium, dye E110 (sunset yellow), macrogol glyceryl hydroxystearate, orange flavor, sucrose, crospovidone, sodium saccharinate, glycerol, citric acid monohydrate, magnesium aluminum silicate, sodium phosphate dihydrate, propylene glycol, propyl parahydroxybenzoate, methyl parahydroxybenzoate and purified water.
The drug is poured into vials:
- dark glass of 100 grams plus a dosing spoon;
- plastic 100 grams plus dosing syringe.
Each of the bottles has its own pack of cardboard paper.
Terms and conditions of storage
Storage of the drug is permissible for no more than three years in a single package. After opening, it can not be used for more than six months. Storage temperature up to 25 degrees, dimming is required.
Pharmacology
As a non-steroidal anti-inflammatory drug, Ibufen is capable of providing analgesic, anti-inflammatory, and fever-reducing effects.
The main factor that determines the mechanisms of action of the drug is the ability to inhibit the activity of the main enzyme of the metabolic process, arachidonic acid (COX), which is known as a precursor of prostaglandin, which plays a major role in the processes of inflammation, pain and fever.
External use of the drug helps to relieve pain and eliminate inflammation. With its help, you can achieve a decrease in stiffness in the morning and increase the range of joint movements.
Pharmacokinetics
After the drug is taken orally, it is immediately completely absorbed from the digestive tract. The combination of medication and food can slow down the rate of absorption.
Metabolism is carried out in the liver. The half-life is not more than three hours.
The excretion of the drug is carried out with urine by 80 percent, of which the main part (70%) is metabolites. In an unchanged form, excretion occurs by 10 percent, and the remaining amount of the drug will be excreted in the intestines in the form of metabolites.
Ibufen for children indications for use
Prescription of the drug is carried out mainly for patients childhood when identifying the following diseases and conditions when the body temperature is elevated or there is a pronounced pain syndrome:
- colds;
- injury to the musculoskeletal apparatus with the subsequent development of joint and muscle pain;
- influenza, SARS;
- neuralgia;
- tonsillitis (tonsillitis);
- migraine or other type of headache;
- infections specific to children;
- pain in the ear (in the inflammatory process of the middle ear);
- reactions after vaccination;
- toothache or painful teething.
The drug is indicated for pain relief and symptomatic therapy. The progression of the disease does not relieve.
Contraindications
The drug has a whole list of contraindications, which must be taken into account when prescribing. Ibufen for children is not recommended for use in
- high degree of susceptibility of the patient to the components of the drug;
- in diseases that are associated with blood clotting disorders;
- with bronchial asthma, complete and incomplete combination with pollinosis of the nose or paranasal sinuses, as well as with intolerance to acetylsalicylic acid;
- with a deficiency of isomaltose, sucrose detected in a patient;
- with diseases of the digestive tract of an erosive-ulcerative nature, especially during exacerbation;
- with detected renal (liver) insufficiency, the degree of which is severe, or with any progressive renal (liver) disease;
- hyperkalemia identified and confirmed
- fructose intolerance, glucose-galactose malabsorption;
- inflammatory processes in the intestines;
The appointment of the drug is allowed only from the age of three months of the child.
Caution in the use of the drug is required:
- with cirrhosis of the liver with portal hypertension;
- with diabetes;
- in the presence of kidney (liver) insufficiency;
- with arterial hypertension;
- in the treatment of corticosteroids (oral), antiplatelet agents, anticoagulants;
- in the presence of chronic heart failure;
- with severe somatic diseases;
- with nephrotic syndrome;
- with the duration of taking this group of drugs (NVPS);
- in the presence of hyperbilirubinemia;
- with blood diseases, the etiology of which is not clear;
- with the presence of Helicobacter pylori;
- with diseases of the digestive tract (ulcers, gastritis, colitis, enteritis).
The drug should be taken after eating inside.
Shake the bottle before each use of the medicine.
The main determining factor in dosing is the child's weight and age. A single dose of the drug is limited to 5-10 milligrams per kilogram of body weight up to four times a day. The daily dose should not exceed 30 milligrams per kilogram of the baby's weight.
A single dose can be carried out at intervals of 6 to 8 hours without exceeding the daily dosage of the drug.
Babies from 3 months. up to six months in case of reactions to vaccinations, 2.5 milliliters are prescribed with a repetition of the dose, if necessary, after six hours. More than 5 milliliters are not allowed per day.
This drug is allowed to be taken:
- as a means to eliminate heat for no more than three days;
- as a pain reliever for no more than five days.
Only a doctor can increase the duration of admission.
Dosing Syringe Guide
- by pressing and indenting towards the bottom, followed by turning counterclockwise, remove the cap from the vial;
- with an effort to press the dispenser into the neck of the container;
- shake the bottle well;
- to fill the dosing syringe, turn the bottle upside down and slowly moving the syringe plunger down to draw liquid to the required mark;
- return the bottle to its previous position and pull out the dosing device with rotating movements;
- enter the contents of the syringe into the child's mouth by slowly pressing the piston;
- at the end of the procedure, close the vial with a lid, and rinse and dry the syringe.
Ibufen for children during pregnancy
During pregnancy, Ibufen is prescribed in exceptional cases - when there is an urgent need for the treatment of a woman.
Ibufen D for children
Ibufen D is allowed for children only from the age of three months. From three months to six months, use only as directed by a pediatrician.
Side effects
The drug has a wide range of side effects, given that the appointment can avoid the risk of developing many complications of the child's condition.
Digestive system
- Patients complain of nausea (vomiting), discomfort with pain manifestations in the epigastric region, loss of appetite, development of flatulence, heartburn, diarrhea;
- in some cases, there was ulceration of the mucous membranes in the mouth, on the gums in the digestive tract, drying of the mucous membranes, the development of hepatitis, pancreatitis, the occurrence of constipation;
Respiratory system
- in the form of bronchospasm, shortness of breath;
nervous system
- There were complaints of headaches and dizziness, depressive states, drowsiness and sleep disturbances, there was anxiety and agitation of a psychomotor nature, hallucinations, confusion and irritability were not excluded. In those patients who suffer from autoimmune diseases, in rare cases, the development of aseptic meningitis was recorded.
sense organs
- There are violations in the auditory zone: decreased hearing, the occurrence of ringing or noise in the ears;
- disturbances in the visual zone: optic neuritis, the nature of which is reversible, the manifestation of visual fuzziness, impaired color vision, the development of scotoma or amblyopia, eye irritation accompanied by its dryness, swelling of the eyelids and conjunctiva of an allergic nature.
Cardiovascular system
- heart failure (development or aggravation), increased blood pressure, symptoms of tachycardia;
Hematopoietic system
- the development of anemia, leukopenia, thrombocytopenia, agranulocytosis and other similar ailments;
urinary system
- There have been cases of acute renal failure, cystitis, allergic nephritis, nephrotic syndrome expressed by edema, polyuria.
Allergy
- Allergy manifestations were observed in the form of skin itching and rash, allergic rhinitis, angioedema, eosinophilia, anaphylactoid reactions, toxic epidermal necrolysis, anaphylactic shock, exudative erythema multiforme, development of bronchospasm, feverish conditions.
Miscellaneous
Many patients complained of increased sweat separation.
If you experience any of the side effects, you should immediately consult a doctor and stop taking medicinal product.
Overdose
Symptoms of an overdose of the drug Ibufen can be various manifestations. Therefore, when a child develops
- pain in the abdomen;
- atrial fibrillation;
- nausea accompanied by vomiting;
- bradycardia;
- state of inhibition;
- tachycardia;
- headaches;
- violations of the functionality of the liver;
- tinnitus;
- acute renal failure;
- depressive state;
- respiratory arrest;
- drowsiness;
- convulsions;
- metabolic acidosis;
- falling blood pressure;
- hemorrhagic diathesis;
should be contacted immediately medical care. Overdose symptoms are especially severe in children under five years of age, expressed mainly by the development of convulsions, apnea or coma.
When an overdose exceeded 400 milligrams per kilogram of the child's weight, a situation is created that seriously threatens the life and health of the baby. In order to avoid serious consequences of the toxic effects of the drug on the body, you should seek help as soon as possible.
Overdose should be treated with rapid treatment by gastric lavage. Activated charcoal, alkaline drinking is prescribed. It is advisable to carry out symptomatic therapy.
Drug Interactions
In order to avoid a decrease in the anti-inflammatory effect and an increase in side effects, one should refrain from taking Ibufen simultaneously with other drugs of the NVPS group.
You should not combine Ibufen with diuretics, as this can lead to a decrease in their effectiveness and increase the risk of kidney failure.
When combined with Ibufen, the hypotensive activity of vasodilators decreases.
The drug enhances the effectiveness of oral hypoglycemic agents, as well as insulin.
An increased risk of developing severe hepatoxic reactions can be expected when Ibufen is combined with inducers of microsomal oxidation (rifampicin, phenytoin, barbiturates, tricyclic antidepressants, phenylbutazone, and ethanol).
Absorption of Ibufen will be reduced under the influence of antacids.
Hypoprothrombinemia develops more often when Ibufen is combined with valproic acid, cefotetan, cefoperazone and other similar medicines.
The hematotoxicity of the drug Ibufen will manifest itself more strongly when exposed to drugs with myelotoxic action.
Combination with gold preparations and cyclosporins leads to an increase in the synthesis of prostaglandin in the kidney area under the influence of Ibufen, which serves as a development of an increase in the nephrotoxic effect.
Plasma concentrations of cyclosprin increase when combined with ibuprofen, increasing the risk of hepatoxicity.
The plasma concentration of ibuprofen will increase and its excretion will decrease when taken simultaneously with those drugs that are capable of blocking tubular secretion.
Ibufen enhances the action of the following drugs: antiplatelet agents, indirect anticoagulants, fibrinolytics, which is fraught with hemorrhagic complications.
Ibuprofen helps to increase the concentration of digoxin, lithium preparations and methotrexate in the blood.
Combining Ibufen with caffeine enhances pain relief.
Additional instructions
With prolonged use of the drug, the functionality of the kidneys and liver, as well as the peripheral blood picture, should be monitored.
For some studies, the patient is asked to cancel the drug two days before they are carried out.
During the treatment period, drugs containing ethanol should not be taken.
In order to avoid unwanted side effects from the digestive tract, Ibufen is recommended to be taken in doses of the lowest effective and as short courses as possible.
Since the side effects of the drug Ibufen are often quite serious, you should, during treatment, engage in activities related to mechanisms and driving any vehicles as little as possible.
Ibufen children's analogues
Analogues of the drug Ibufen, which can successfully replace the drug if necessary, can be considered medicines: Advil for children, Ibuprofen-Hemofarm, Nurofen for children, Ibuprofen. Each of them is available in suspension form.
Ibufen for children price
The cost of the drug is not high and does not exceed 85 rubles.
Ibufen children's reviews
Judging by the reviews, the drug Ibufen is very popular with parents of babies as an effective antipyretic and analgesic. Many praise not only the effectiveness of the drug, but also a convenient form of release, as well as simple dosing. According to the parents, there is no problem to give medicine to the baby with the help of dosing devices, as well as due to its pleasant aroma and taste.
There are a lot of reviews and each of them praises and recommends Ibufen to those who are not familiar with it yet. We present, perhaps, for clarity, some of them.
Nina: When my daughter, having come from the kindergarten, began to literally “burn”, I rushed to the first-aid kit at home. Antipyretic candles brought down the temperature a little and the thermometer recorded 39.5 degrees, but the effect was not long. Frightened by the further unfavorable development of events, I called the doctor. We were recommended Ibufen for children. I must say, he put the child on his feet in a jiffy. After the temperature was brought down, no cold symptoms followed. Virus. Now Ibufen has also settled in our medicine box.
Svetlana: As a toddler, our son was often sick and each time, the temperature rose quite high. I was always saved by Nurofen, until I was advised at the pharmacy for its absence, the drug Ibufen. It turned out that there is no difference between them, except for the cost, and it seemed to me that Ibufen helped faster and more efficiently. Now we are expecting a second baby and we are no longer afraid of colds and viruses. After all, we know about Ibufen.
Ibufen D is probably the most popular antipyretic for children, but Ibufen D is contraindicated in children under 6 months (body weight less than 7 kg).
Ibufen D - suspension for oral administration: as an antipyretic: for colds, acute respiratory viral infections, influenza, tonsillitis (pharyngitis), childhood infections accompanied by fever, post-vaccination reactions.
Ibufen D is a non-steroidal anti-inflammatory drug that also has analgesic and antipyretic effects. Refers to preparations containing a derivative of propionic acid ibuprofen.
Instructions for the medical use of the medicinal productIBUFEN D
Tradename
International non-proprietary name
ibuprofen
Dosage form
Oral suspension 100 mg/5 ml
Ingredients of Ibufen D
5 ml suspension contains
active substance- ibuprofen 100 mg,
excipients: macrogolaglycerol hydroxystearate, xanthan gum, glycerol, sodium benzoate, citric acid monohydrate, sodium phosphate dihydrate or sodium phosphate dodecahydrate, sodium saccharinate, liquid maltitol, orange flavor, purified water.
Description of the drug Ibufen D
Suspension of white or almost white color with sapelsino smell.
Pharmacotherapeutic group
Non-steroidal anti-inflammatory drugs (NSAIDs), propionic acid derivatives.
ATC code: M 01 AE 01
Pharmacological properties of the drug Ibufen D
Pharmacokinetics
When taken orally, more than 80% of ibuprofen is absorbed from gastrointestinal tract, reaching the maximum concentration in the blood plasma after 1 hour. Eating slows down the absorption of ibuprofen, but does not reduce its bioavailability. When taking ibuprofen in the form of a suspension in children at a dose of 10 mg / kg, its maximum concentration in the blood is 55 μg / ml. Ibuprofen when taken with food is absorbed more slowly: (t max) while 30-60 minutes longer than when taken on an empty stomach and is 1.5-3 hours.
Ibuprofen binds to plasma proteins by more than 99%. The major drug-binding proteins are albumins. The volume of distribution of ibuprofen in adults is about 0.12 l / kg of body weight, but in children with fever under 11 years of age it is higher and is about 0.2 l / kg of body weight. A high degree of protein binding limits the rate of penetration of ibuprofen into the synovial and cerebrospinal fluid. Therefore, ibuprofen slowly penetrates into the synovial fluid, maintaining a therapeutic concentration in it for a long time. The drug is biotransformed mainly in the liver. 70-90% of the dose taken is excreted in the urine in the form of metabolites and products of their conjugation with glucuronic acid.
The rest of the dose is excreted in the feces unchanged and also in the form of metabolites. The drug does not accumulate in the body.
The half-life is 2 - 2.5 hours.
Pharmacodynamics
Ibuprofen is a propionic acid derivative that has antipyretic, analgesic and anti-inflammatory effects.
The mechanism of action of ibuprofen is primarily due to the suppression of prostaglandin biosynthesis by reducing the activity of cyclooxygenase (COX), an enzyme that regulates the conversion of arachidonic acid into prostaglandins, prostacyclin and thromboxane. At the same time, as a result of irreversible inhibition of the cyclooxygenase pathway of arachidonic acid metabolism, the formation of prostaglandins decreases. A decrease in the concentration of prostaglandins at the site of inflammation is accompanied by a decrease in the formation of bradykinin, endogenous pyrogens, other biologically active substances, oxygen radicals and NO. All this leads to a decrease in the activity of the inflammatory process (anti-inflammatory effect of ibuprofen) and is accompanied by a decrease in pain reception (analgesic effect). A decrease in the concentration of prostaglandins in the cerebrospinal fluid leads to the normalization of body temperature (antipyretic effect). The effect of lowering the temperature begins 30 minutes after ingestion, its maximum effect is manifested after 3 hours.
Ibufen D - suspension has antipyretic, analgesic, anti-inflammatory effect. Reduces the manifestation of symptoms such as fever, pain and swelling, by acting at the site of their occurrence.
Indications for use of the drug Ibufen D
Ibufen D is intended for use in complex therapy in children in the following cases:
- acute respiratory viral infections
- flu
- angina (pharyngitis)
- childhood infections accompanied by fever
- post-vaccination reactions
- ear pain due to inflammation of the middle ear
- toothache, painful teething
- headache, migraine
- pain in muscles, joints
- musculoskeletal injuries
Dosage and administration of Ibufen D
For oral use.
5 ml of suspension contains 100 mg of ibuprofen.
Shake before use until a homogeneous suspension is obtained.
The drug is taken after meals, with plenty of water.
For accurate dosing of the suspension, a dispenser (spoon or syringe) is attached to the vial.
The dose is set depending on the age and body weight of the child.
A single dose of Ibufen D is 5-10 mg/kg of the child's body weight 3-4 times a day. The maximum daily dose of the suspension is 20-30 mg/kg of body weight, not more. The drug is prescribed in single doses according to the scheme below:
Infants from 3 to 6 months (5-7.6 kg): 2.5 ml 3 times a day (corresponding to 150 mg of ibuprofen per day).
Infants from 6 to 12 months (7.7-9 kg): 2.5 ml 3 to 4 times a day (corresponding to 150 mg-200 mg ibuprofen/day).
Children from 1 year to 3 years (10-15 kg): 3 times 5 ml during the day (corresponding to 300 mg of ibuprofen per day).
Children from 4 to 6 years (16-20 kg): 7.5 ml 3 times a day (corresponding to 450 mg of ibuprofen per day).
Children from 7 to 9 years old (21-29 kg): 10 ml 3 times a day (corresponding to 600 mg of ibuprofen per day).
Children from 10 to 12 years old (30-40 kg): 15 ml 3 times a day (corresponding to 900 mg of ibuprofen per day). Do not exceed the indicated dose.
The dose can be repeated every 6-8 hours, with an interval of at least 4 hours between successive doses.
Children under 6 months of age can use the drug after consulting a doctor in accordance with his recommendations. Do not exceed the recommended dose.
With post-vaccination reactions in children from 3 to 6 months, as prescribed by a doctor.
Duration of treatment:
No more than 3 days as an antipyretic
No more than 5 days as an anesthetic
If the fever persists for more than 3 days, a doctor should be consulted.
Instructions for use dispenser in the form of a syringe
1. Unscrew the cap from the vial (press down and turn counterclockwise).
2. Press the dispenser firmly into the opening of the bottle neck.
3. Shake the vial vigorously.
4. To fill the dispenser, the bottle must be turned upside down, and then carefully move the dispenser piston down, pour the contents until the desired mark on the scale is reached.
5. Turn the bottle upside down and remove the dispenser from it by carefully unscrewing it.
6. Place the tip of the dispenser in the child's mouth, and then, slowly pressing the piston, introduce the contents of the dispenser.
7. After use, the bottle should be closed by screwing the cap, and the dispenser should be rinsed with water and dried.
Side effects of the drug Ibufen D
Usually the drug is well tolerated, however, its use in some individuals may cause side effects from the digestive tract, such as stomach discomfort, nausea, vomiting, abdominal pain, loss of appetite.
Rare side effects include:
nonspecific allergic and anaphylactic reactions
reactions from the respiratory system, manifested by bronchospasm or suffocation, exacerbation of asthma
skin reactions in the form of rashes, itching, urticaria, purpura, vasomotor edema, very rarely bullous dermatosis, exudative erythema, epidermal necrolysis
thrombocytopenia, anemia, leukopenia
erosive and ulcerative lesions of the gastrointestinal tract
headaches, dizziness, insomnia, excitability, irritability, drowsiness, depression, tinnitus
Contraindications
individual hypersensitivity to any component of the drug, as well as to other non-steroidal anti-inflammatory drugs
symptoms of allergy in the form of a runny nose, skin rashes or bronchospastic reactions after the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs
peptic ulcer of the stomach and duodenum in the acute phase, ulcerative colitis, Crohn's disease
severe insufficiency of liver and kidney function
blood diseases: hemophilia, hypocoagulation, hemorrhagic diathesis
III trimester of pregnancy
children's age up to 3 months
Drug Interactions
Ibuprofen (as well as other drugs of the group of non-steroidal anti-inflammatory drugs) should not be used simultaneously with the following drugs:
acetylsalicylic acid, paracetamol or other non-steroidal anti-inflammatory drugs - the risk of side effects from the gastrointestinal tract increases
antihypertensive drugs and diuretics - drugs from the group of non-steroidal anti-inflammatory drugs can cause a decrease in the effectiveness of these drugs,
anticoagulants - few clinical data indicate that non-steroidal anti-inflammatory drugs may increase the effect of drugs that reduce blood clotting
lithium and methotrexate - non-steroidal anti-inflammatory drugs have been shown to cause an increase in plasma concentrations of both lithium and methotrexate
zidovudine - there is evidence of an increase in bleeding time in patients taking both ibuprofen and zidovudine
special instructions
If any side effects occur, stop using Ibufen D and tell your doctor.
The expected benefits and possible risks should be assessed before prescribing Ibufen D to a child if the child: aged 3 to 6 months.
Before taking the drug Ibufen D, you should consult your doctor if you have previously confirmed:
Bronchial asthma, urticaria,
Diseases of the liver and kidneys,
Peptic ulcer of the stomach and duodenum in history.
The drug Ibufen D does not contain sugar, so it can be used in people with diabetes.
The drug does not contain dyes and can be used in children prone to allergic reactions to dyes in the recommended dosages.
Special care should be taken in individuals with hereditary fructose intolerance.
Pregnancy and lactation
The use of ibuprofen in the first 6 months of pregnancy requires caution and is allowed only on prescription, after assessing the expected benefits and possible risks. Do not use ibuprofen during the last trimester of pregnancy.
Ibuprofen can be excreted in small amounts in breast milk. There are no known cases of side effects in infants, however, it is recommended to stop breastfeeding during treatment with ibuprofen.
Influence on the ability to drive motor vehicles and maintain mechanical equipment.
There is no information on contraindications to driving and maintaining machinery while taking Ibufen D.
Overdose
If you take a higher dose of the drug than recommended, you should immediately contact your doctor or pharmacist.
Symptoms: increased symptoms of side effects, abdominal pain, nausea, vomiting, headache, tinnitus, acute renal failure, bradycardia.
Treatment: no specific antidote, gastric lavage and, if necessary, correction of electrolyte disturbances, alkaline drinking, symptomatic therapy, supportive therapy is used,
Release form and packaging
120 ml in glass bottles with a screw cap with a guarantee ring and a dosing spoon or 120 ml in plastic bottles with a screw cap with a guarantee ring and a dosing syringe. Each bottle, along with instructions for use in Russian, is placed in individual cardboard boxes.
Storage conditions
Store in original packaging at temperatures between 15°C and 25°C.
Keep out of the reach of children!
Shelf life
After the first opening of the package, the vial must be used within 6 months.
Do not use the drug after the expiration date.
Holiday conditions
Without recipe
Manufacturer
"Medana Pharma" JSC
98-200 Sieradz, st. V. Loketka 10, Poland
Save to social networks:Ibufen is a modern antipyretic and analgesic drug based on Ibuprofen, which can alleviate the condition of a sick adult or child in 30 minutes.
Therapists and pediatricians without fear prescribe this medication to their large and small patients as part of the complex therapy of influenza, tonsillitis, SARS, pain in the joints, bones and muscles.
On this page you will find all the information about Ibufen: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Ibufen. Want to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Terms of dispensing from pharmacies
Released without a prescription.
Prices
How much does Ibufen cost? The average price in pharmacies is at the level of 80 rubles.
Release form and composition
On the this moment pharmacological agent has several forms of release. Among them:
- Ibufen D is a syrup for oral use. A 120 ml plastic bottle is used as packaging. The content of ibuprofen is 100 mg per 5 ml of solution. A special syringe is attached as a dispenser;
- Ibufen for children comes in the form of 200 mg tablets. Available in blisters of 10 or 20 tablets each. The packaging must be marked that the drug is intended for children;
- Ibufen Forte is an oral suspension of enhanced action. The content of ibuprofen is 200 mg per 5 ml of solution. The syrup is available in a 100 ml plastic bottle;
- oral suspension. Produced in bottles of 100 ml each with a measuring spoon included. The syrup has a citrus smell and a sweetish aftertaste. Before use, the drug should be shaken;
- Ibufen Ultra is an enhanced form of release of the drug in the form of blue capsules. The concentration of Ibuprofen is 200 mg in one capsule. Packages are available in which there are 1 or 2 blisters. Each contains 10 capsules.
Pharmacological effect
The main active ingredient of the drug - ibuprofen - has an anti-inflammatory, as well as antipyretic and analgesic effect on the human body (the latter is most pronounced with pain of an inflammatory nature of origin).
The mechanism of action of the drug is due to the ability of ibuprofen to have an inhibitory effect on the synthesis of prostaglandins by inhibiting cyclooxygenase, an enzyme that plays an important role in the metabolism of arachidonic acid and the formation of prostaglandins. And this, in turn, leads to inhibition of the severity of the inflammatory process, a decrease elevated temperature body and generation of pain impulses through nerve structures.
Indications for use
According to the instructions, Ibufen is intended for use in:
- The presence of an inflammatory process in the small pelvis, including during childbirth (in these cases, Ibufen is used as a tocolytic (preventing premature birth) and an anesthetic);
- Feverish syndrome caused by infectious and catarrhal diseases;
- Pain syndrome: with myalgia, radiculitis, arthritis, dental and headache (including those caused by menstrual syndrome) pain, ossalgia, arthralgia, myalgia, neuralgia, tendovaginitis, tendinitis, bursitis, neuralgic amyotrophy, oncological pain, postoperative and post-traumatic pain, if they accompanied by inflammation
- Inflammatory and degenerative diseases of the musculoskeletal system, such as: osteochondrosis, psoriatic, rheumatoid and chronic juvenile arthritis, Parsonage-Turner disease (or neuralgic amyotrophy), arthritis caused by systemic lupus erythematosus (as one of the complex therapy drugs), Bechterew's disease ( or ankylosing spondylitis), gouty arthritis.
Contraindications
Ibufen is contraindicated in:
- nasal polyps;
- hearing loss;
- Hemophilia, hemorrhagic diathesis or other blood clotting disorder;
- Deficiency of glucose-6-phosphate dehydrogenase;
- Exacerbation of peptic ulcer of the stomach or duodenum;
- angioedema;
- Severe violations of the liver / kidney function;
- Known hypersensitivity to ibuprofen, acetylsalicylic acid (ASA) or any other NSAID;
- Hypersensitivity to any auxiliary component;
- A history of a case of bronchospasm after taking ASA or another NSAID.
The drug is contraindicated in children under 6 months of age or weighing less than 7 kg. Children aged 6-12 months can only be given Ibufen if prescribed by a doctor.
It is possible to use the drug, but under close medical supervision with:
- Dyslipidemia;
- Ischemic heart disease;
- Presence of Helicobacter pylori infection;
- Hyperbilirubinemia;
- Severe somatic diseases;
- Liver/renal failure;
- Leukopenia, anemia;
- The need for long-term use of the drug;
- Diseases of peripheral arteries;
- diabetes mellitus.
- Severe heart failure.
- arterial hypertension;
- Peptic ulcer of the stomach and duodenum in history;
- nephrotic syndrome;
- Obstructive lung diseases and bronchial asthma;
- Cerebrovascular diseases;
- Cirrhosis of the liver with portal hypertension.
With extreme caution, Ibufen is also prescribed to elderly patients, people who abuse alcohol and / or smoke.
Use during pregnancy and lactation
The use of Ibufen is contraindicated in the third trimester of pregnancy.
There are no studies on the effect of Ibufen during breastfeeding. However, if there is a need for its use, breastfeeding should be stopped for the period of taking the drug.
Instructions for use
The instructions for use indicate that Ibufen Forte, Ibufen D, as well as simple Ibufen - the average single dose for adults is 5-10 mg per 1 kg of body weight, repeated 3-4 times during the day. The maximum daily amount of the drug taken should not exceed 30 mg per 1 kg of the patient's weight. The course of conservative therapy is prescribed individually by the attending physician, as it must be consistent with the indications for treatment and regular diagnostic indicators of the body.
Ibufen Suspension is taken by mouth (by mouth) after a meal. Dosage depends on age:
- Children aged six months to 1 year - 2.5 ml (50 mg ibuprofen) 3 times a day, not more than 7.5 ml.
- Children aged 1 to 3 years - 2.5 ml 3-4 times a day, depending on the severity of pain, temperature or inflammatory changes. Not more than 10 ml.
- Children aged 3 to 6 years - 5 ml (100 mg ibuprofen) 3 times a day, the maximum dose during the day should not exceed 15 ml.
- Children aged 6 to 9 years - 5 ml 4 times a day, no more than 20 ml per day.
- Children aged 9 to 12 years - 10 ml 3 times a day, no more than 30 ml of suspension per knock.
- Children over the age of 12 years - 10 ml 4 times a day (no more than 20 ml per day).
Usually, the suspension is taken every 6-8 hours during the day. Do not exceed the maximum allowable daily dose. For children aged 6 months to 1 year, the drug can be used only as directed by a doctor.
Side effects
At conservative treatment Ibufen may experience the following undesirable effects:
- From the hematopoietic system: heart failure, tachycardia, thrombocytopenia, anemia, increased blood pressure, leukopenia (manifested as agranulocytosis).
- From the side of the central nervous system: dizziness, headache, sleep disturbance, anxiety, drowsiness, depression, reversible toxic amblyopia, blurred vision, diplopia - double vision.
- Urinary system: acute renal failure, nephrotic syndrome, which is manifested mainly by edema, polyuria, cystitis, inflammation of the renal apparatus.
- Digestive system: dyspeptic indigestion, diarrhea, loss of appetite, heartburn, constipation, flatulence, impaired excretory function of the liver, peptic ulcers of the stomach with hemorrhagic outcome.
- Allergic reactions: skin itching and rash, bronchospastic syndrome, rhinitis, Quincke's angioedema, Stevens-Johnson and Lyell's syndrome.
Overdose
A significant excess of the recommended therapeutic dose of Ibufen suspension leads to the development of abdominal pain, nausea, vomiting, headache, tinnitus, drowsiness, bleeding different localization and intensity. In this case, the stomach, intestines are washed, activated charcoal or other intestinal sorbents are taken, as well as symptomatic therapy. There is no specific antidote for ibuprofen.
special instructions
- Patients referred for 17-ketosteroid testing should discontinue ibuprofen within 48 hours.
- With prolonged use of Ibufen, it is necessary to monitor the picture of peripheral blood, the functional state of the kidneys and liver.
- To reduce the risk of gastrointestinal side effects, Ibufen should be taken at the lowest effective dose for the shortest possible period.
- To prevent the development of NSAID gastropathy, Ibufen is recommended to be combined with prostaglandin E preparations (for example, misoprostol). When symptoms of the disease appear, careful monitoring of the patient's condition is necessary, including a fecal occult blood test, a blood test with the determination of hemoglobin and hematocrit, and esophagogastroduodenoscopy.
- In bronchial asthma or other diseases that may be accompanied by bronchospasm, ibuprofen can cause the development of bronchospasm. For this reason, the drug should be used only with great caution in these patients. In case of difficulty breathing, you should immediately consult a doctor.
- Patients with diabetes should take into account that 1 ml of suspension contains about 0.34 g of sucrose, or about 0.03 XE. Thus, the minimum single dose of Ibufen (2.5 ml) contains 0.85 g of sucrose (0.075 XE), the maximum single dose (15 ml) contains 5.13 g of sucrose (0.45 XE).
