How to get rid of diffuse changes in the liver. Symptoms and treatment of moderate diffuse liver changes. Diffuse dystrophic liver damage

Stoves, fireplaces 20.06.2021
Stoves, fireplaces

The consistent interaction between atoms or molecules of two substances with the acquisition of one properties and qualities of others, in which the concentration of molecules is equalized throughout the volume of contact substances is called diffusion. Under the influence of many negative factors, the natural reaction is violated, both in the world and in the human body, provoking the violation of the physical balance, the development of diffuse changes.

The risk of diffuse changes of the organs of digestive and excretory systems are especially exposed:

  • Stomach;
  • Liver;
  • Pancreas;
  • Spleen;
  • Intestines;
  • Kidney.

Diffuse changes in the liver can be both quite insignificant and quite serious pathologies.

Diffuse liver changes do not have clear age boundaries, this phenomenon can touch the newborn, and the elderly. In the kids, this phenomenon is called congenital human pathology, and in an elderly person it develops subsequently hepatitis or strong poisoning.

Diffuse liver changes relate to its parenchyma, size and structure of the organ, affect the reduction of the glorification of the artery and veins, the operation of the gallbladder and biliary ducts.

What is a liver parenchyma? Parenkhai liver is called fabric from which, actually, the organ and consists.

Causes of changes

In the case when the changes pass in the sluggish stage, no external symptoms of the disease of the organ is observed.

In the acute stage, such signs of diffuse liver changes are noted:

  • pain, gravity in the right side, under the ribs;
  • colic;
  • increasing body temperature;
  • jaundice;
  • feeling of bitterness in the mouth;
  • noticeable bulge on the skin of the right hypochondrium;
  • digestive disorders;
  • emotional instability, plasticity, aggression.

Diagnostics

Often, a patient who does not feel the process, detects the starting diffuse changes in the liver during a profile. By setting a suspicion of this diagnosis, the doctor prescribes the blood test (general and biochemical), but the unfolded picture of what happened can be obtained by ultrasound.

Advanced preparation necessary for ultrasound examination of diffuse changes in the liver parenchyma is:

  • the exclusion of products that are capable of forming gases per day before the procedure;
  • cleansing the intestines with the help of the enema;
  • reception of antispasmodics in front of a session.

What does ultrasound indicate?

Ultrasound will indicate on diffuse changes in the structure of the liver and organ cells, as well as on violations of their functions.

The doctor will indicate on areas with different echogenicity: reduced, elevated or high. This will indicate development:

  • hepatitis A;
  • amyloidosis;
  • fat or alcohol hepatosis;
  • oncology;
  • helminty lesions.

For example, those indicated by the doctor, sound support and echogenicity indicate the disorders in the liver tissue, increased echogenicity of biliary channels with diffuse liver changes indicates a gallstone disease, cholangitis or cholecystitis. Reduced echogenicity indicates hepatitis.

If ultrasound research is not enough, the doctor can recommend to pass magnetic resonance or computed tomography when the fabrics can be studied step by step.

Treatment

Minor diffuse changes

Minor liver diffuse changes are treated with:

  • hepatoprotectors (for example, essential);
  • diet number 5;
  • if there are no contraindications, it is possible to carry out a tuba.

Essence

In one solid gelatin capsule C, as if honey content, 300 mg of essential phospholipids obtained from soybeans are contained.

These phospholipids are similar endogenous phospholipids, however, are more functional due to the high level of polyunsaturated fatty acids. They have a basic property: embedded in cell membranes of damaged hepatic cells and help the process of their regeneration.

The main dosage for adults and adolescents from 12 years in case of liver diseases is 2 capsules, which should be taken three times a day, not less than 3 months.

But, in the current situation, the doctor is entitled to establish a dosage and course of treatment, depending on the individual characteristics and the flow of the change procedure.

Diet number 5.

In diffuse changes in the liver and its diseases implies refusal to:

  • fried;
  • drift;
  • animal fats (oily meat, salla);
  • sausage products;
  • canned;
  • marinades;
  • mushrooms;
  • legumes;
  • radish, radish, garlic, shrine, green onions and sorrel;
  • acidic fruit and berries;
  • saturated with fats of dairy and fermented milk products;
  • alcoholic and carbonated drinks;
  • coffee, cocoa, strong black tea;
  • semi-finished products and fast food products.

It is important to switch to protein safe meals with the restriction of plant and the exception of animal fats, as well as strict dosing of salt and sugar. In case of disease, focus on cereal, stew, boiled vegetables, soups, low-fat meat and dairy dishes are made.

Moderate diffuse changes

Moderate diffuse liver changes are treated a little differently:

  • hepatoprotectors;
  • diet number 5;
  • antibiotics;
  • antihistamine means;
  • with the addition of a vitamin and mineral complex.

Antibiotics

In the case when in the treatment of the disease without antibiotic therapy, it is often prescribed fluoroquinolones. In their action, a gential attitude towards the cells of the body is especially noted. In particular, Ciprofloxacin (Ciprolet A, Digger, Digger) uses extremely popular.

The effectiveness of ciprofloxacin is observed due to the effects of the antibiotic on the synthesis of DNA in the structure of the bacterium.

The usual daily dose of ciprofloxacin-containing drugs is 2 tablets, which is recommended twice a day, after a 12-hour interval an hour before meals or 2 hours after meals.

Treatment of viral changes

Diffuse changes in viral-liver parenchyma are treated with:

  • antiviral therapy;
  • hormonal means;
  • vitamin and mineral complex;
  • and full nutrition in diet number 5.

Treatment of the bacterial cause of changes

Diffuse changes in the liver and pancreas caused by bacteria are being treated mainly with antibiotics, in particular, aminoglycosides.

Aminoglycosides are one of the first antibiotics, they act due to the destruction of the bacterial chain of the synthesis of protein ribosomes. Recently, amikacin in injections in injections has recently popular.

The injection is placed in muscle tissue.

The solution must be prepared before administration of the drug, the powder in the bottle should be dissolved with water for injection. The dosage is established by the doctor individually, it can be 5 mg per kg of body weight, every 8 or 12 hours. A full course of treatment is 10 days.

Anticline

After graduating from the Course, it is necessary to start the reception of choleretic drugs and go through duodenal sensing.

Changes that occurred due to gallstone disease

In this case, initially, it is customary to treat the disease-root cause of the state, namely, eliminate stones. Next, the doctor will recommend adhering to a strict diet number 5, taking choleretic drugs and hepatoprotectors.

Golden drugs

There are many drugs that enhance the bile current, one of the most commonly appointed can be called Allhol and Hofitol.

Hofitol is a dark solution of saturated brown with a possible yellow sediment. As a rule, it is diluted with water before direct welcome, adults should drink a teaspoon of hofitola before taking food, three times a day.

Diffuse liver changes are a similar group of ultrasound signs that make it possible to conclude a liver tissue involvement in an inflammatory or pathological exchange process. Pathology belong to the most common and, as a rule, is not a specific nature.

The identification of diffuse changes does not mean the presence of some kind of liver disease, but only indicates damage to the hepatic parenchyma. Changes in this type can be detected at any age and most often is only a random find of ultrasonography.

Causes of diffuse changes

Since diffuse changes in liver parenchyma are not an independent liver disease, but only a consequence of the main pathology, then there is a whole group of reasons leading to their appearance. Here and disruption of the nature of nutrition, and disruption of metabolism, and infectious pathology. Among the reasons having the most significant contribution to the etiopathogenesis of the development of hepatic damage can be allocated:

Depending on the cause that caused damage to hepatic cells, diffuse changes may be additionally accompanied by a change in liver size.

As a result, it is possible to highlight changes in the following types:

  • Hypertrophic (increase in liver in size, hepatomegaly);
  • Sclerotic (replacement of liver parenchyma with a connecting cloth);
  • Hypotrophic (reduction in liver size).

In addition, depending on the type of echo, from the modified hepatic parenchyma, you can allocate:

  1. Hyperehogenic diffuse changes (fatty dystrophy, steroid, cirrhosis, Cushing's disease, etc.) - Echos signal is strengthened.
  2. Hypohehogenic diffuse changes (lymphoma, some types of hepatitis) - echo the liver is reduced.

The identification of any type of diffuse change requires compulsory reassembly to establish its cause and adequate therapy.

What do diffuse changes on ultrasound look like

Normally, the liver parenchyma has a homogeneous (homogeneous) structure of the average echogenic level, against the background of which blood vessels and hepatic ducts are distinguished intense inclusions. Assessment of the structure of the parenchyma and the level of its echogenicity is made compared with the renal bark and spleen (the tail fraction of the liver is in the immediate vicinity of the cortex of the right kidney).

As a rule, the normal hepatic parenchyma is the same or a little more echogen than the kidney bark and less echogenna than the spleen. The change in echogenicity already indicates the presence of diffuse changes.

The liver has clear, well-defined borders ultrasound scanning. The boundaries of the liver can be sharply and intensively differentiated in the presence of ascites (complicated during the liver disease). In the liver parenchyma, multiple anechogenic / hypo echogenic tubular or round structures are normal. They are hepatic veins.

Intrahranny bile ducts and hepatic arterys are not visually visualizedif their size does not exceed the maximum valid values. The size of the portal vein may vary depending on the respiratory cycle. When detecting foci of strengthening or reduce the echoes from the liver tissue, outside the blood vessels or outside the bile ducts also talk about diffuse hepatic changes.

What is estimated at ultrasound

When conducting ultrasound scanning, to assess the presence of diffuse pathology of the liver and pancreas, be measured:

  1. Longitudinal and transverse liver size.
  2. Echogenic level, presence of hypo / hyperheogenic inclusions.
  3. The degree of vascularization of the liver tissue.
  4. Anomalies that are not associated with the hepatic parenchyma (increase in local lymph nodes, deformations of the gallbladder, the pathology of the pancreas, spleen, etc.).

Based on the total estimate of the above parameters and an assessment of the degree of severity of diffuse changes is made.

Diseases expressed by diffuse changes

Diseases that influence the structure of hepatic parenchyma are called diffuse liver diseases. They occur during damage to hepatocytes and substituted by their pathological tissues, which leads to a decrease in the liver function. The ultrasonographic view of the liver may vary depending on the disease underlying damage.

Among other things, the ultrasonic picture of the liver changes and as the disease progressing in combination with increasing laboratory changes.

The most common types of diseases characterized by the presence of diffuse liver changes are most often:

  1. Fat hepatosis is a substitution of liver tissue with fat cells, which leads to an increase in its echogenicity, an increase in liver in size, as well as to change the ultrasonic structure of the liver. Fatty tissue is poorly contoured by ultrasound. That is why the liver at fat hepatosis looks hypo echo (by the type of fat hepatosis or by the type of fatty infiltration).
  2. Viral hepatitis - constant inflammation in hepatocytes leads to damage and edema, which is also expressed by diffuse changes on the ultrasound. The liver is compacted, the degree of parenchyma fibrosis is growing, which is manifested by the amplification of the echo signal.
  3. Cirrhosis of the liver is the basis of the appearance of pathological changes in ultrasonography is almost complete substitution of the normal hepatic tissue by cutting structures, which leads to its significant sealing and impaired hepatic function.
  4. Stones in bile ducts and a bustling bubble, leading to) - cholestasis (stagnation of bile in hepatic pathways), leads to the expansion of intrahepatic bile ducts, which is instrumental manifest as diffuse changes.
  5. - A constantly elevated level of blood glucose leads to its deposition in the form of glycogen (followed by the transition to fat stocks) in liver cells. The liver increases in size and is chronically damaged.

Survey

To identify the exact cause of the development of diffuse liver changes, it is necessary to undergo a whole range of diagnostic studies, including:

  1. Study of the function (hepatic samples, bilirubines, alkaline phosphatase, GGTP, assessment of the coagulogram, plasma protein level and albumin, protein fractionation).
  2. Assessment of the metabolic condition (blood glucose, lipidogram, thyroid hormone levels, insulin level, serum iron, transferin).
  3. Assessment of the state of the intestine and stomach (if there are symptoms - FGDS, FCC, a coprogram, feces for hidden blood).
  4. Examination for the presence of viral hepatitis.

In addition to the above-mentioned types of research, the doctor may be additionally appointed MRI or MSCT of internal organs, which will make it possible to consider the type of diffuse pathology in more detail.

Treatment

Therapy of diffuse liver changes should be complex and aimed at the causeloving their appearance. For all sick it is recommended:

  1. Diet and therapy with orientation on.
  2. Frequent, fractional food.
  3. Mineral water.
  4. Hepatoprotectors (Ursosan, Heptral, Esssential, etc.).

Additionally, depending on etiology, it is possible to use funds that affect metabolism, vitaminotherapy, antiviral treatment. All kinds of therapy should be appointed only by the attending physician, individually for your type of pathology. Self-treatment is not permissible and can lead to complications and progression of the main disease.

Diffuse liver changes are not a separate disease, but a uniform deviation from the normal structure. Changing the tissue of the largest gland organism itself is found during, additional analyzes and surveys based on clinical development, as well as on complaints of human medical care. According to the results of diagnostic procedures, the doctor will diagnose and prescribe treatment if necessary.

What is diffuse changes in the liver and what they happen

The liver is the only body that impedes the flow of poisonous products into the bloodstream. It is necessary to find out what the liver parenchyma is, and how affects health changes in its condition.

The fabric from which the liver is called a parenchymal. The growth of parenchymal fabric or its decrease is observed during diffuse focal changes. They are both insignificant and volumetric.

The structure of the parenchyma is the structure of the connective tissue, which is seduced by the liver. It consists of a variety of cells on which vessels and bile canals are located.

  • The liver in healthy people has a fine-grained structure, clear and smooth contours.
  • The incorrect metabolism leads to the identification of parenchyma mediterranean echoes.
  • The coarse structure is possible to observe with diabetes, alcoholism.
  • Various diseases provoke the appearance that leads to a change in the liver parenchyma density.

Violations in the work of the internal organs lead to reactive changes in the liver parenchyma in the child. Similar changes in children are explained by the insufficiency of the digestive tract and its diseases. A frequent reasons for the disease include the presence of helminths in the child's body.

What diseases can lead to changes in the organ parenchyma

Changes in the liver parenchyma are detected under such conditions:

One of the most pressing problems of gastroenterology is the therapy of chronic diffuse liver diseases. Among them allocate minor, severe and moderate diffuse changes. The normal condition of the liver tissue during ultrasound is expressed in the presence of the same density throughout the body. Uniform increase or decrease in density is the echo drive of diffuse changes.

Fat exchange disorder in hepatic tissue (steatohepatosis or fatty infiltration) is associated with gradual reincarnation of hepatic cells into fatty tissue. Timely and treatment are able to fully restore the functions of the damaged organ.


Related treatment or ignoring the first manifestations of the disease is fraught with the destruction of the liver. There is a danger of the development of a cirrhosis leading to the death of the patient.

Additional symptoms of liver pathology

When examining internal organs with ultrasound, doctors often detect a violation in the form of diffuse liver seal. Since the normal operation of this internal body is vital for a person, such a sign can be considered anxious. Changes in organ tissues are signs of diseases:

  1. . Changes are not entirely distinct.
  2. Obesity and diabetes. The liver is noticeably enlarged in size ,.
  3. Tumors. Changes are located in one of the share of the organ.
  4. . There is rebirth of the tissue of the organ, the cells are restored themselves.
  5. Cirrhosis. The inhomogeneous structure of the body, there are multiple affected areas.

In addition to ultrasound signs, there are subjective symptoms:

  • A pronounced feeling of gravity in the field of right hypochondrium.
  • , Persons, Language.
  • Dark urine and light feces.
  • Problems with digestion.
  • Constant fatigue, drowsiness, irritability.

Diagnostics

Liver cells are not always able to cope with the organism penetrating or the poisons formed in it. In some cases, poisoned cells die, and instead they appear connective (fibrous) fabric. It does not replace the functions of hepatocytes and has other echogenicity. Echographic signs of moderate diffuse changes are detected only during. This diagnostic method allows you to establish, identify possible changes in its structure, examine the tubercles, irregularities, swelling lymph nodes.

The presence of an inhomogeneous liver echoment indicates cirrhosis. The inhomogeneity of the parenchyma is also different in which the liver is compacted, the connecting tissue is expanding.

In addition to ultrasound, the state of this body can be checked by analyzing blood on biochemistry and general urine analysis. In samples, especially.

Treatment of diffuse liver changes

In its natural condition, the liver is homogeneous. Blood vessels and gall canals pass through her tissues. In the same cases, when the liver parenchyma is diffuse, which was discovered during the ultrasound, the need for emergency treatment appears.

The impact on the liver of many adverse factors can lead to the emergence of echo-discovers of the reactive changes in Parenhim. Typically, the cause of such a diagnosis, in particular, reactive hepatitis, are not liver damage or fails to work, but the other problem. As a result of the disease, the biochemical blood content changes, so timely treatment is extremely necessary in this situation.



Treatment is carried out in two ways - conservative and surgical. Increased pressure in a portal vein, metastases, tumors require operations to remove neoplasms. In other situations, treatment is carried out by drugs.

Diet and auxiliary methods

Regardless of the reasons, a diet with diffuse liver changes plays a significant role. The first thing the doctor will appoint a svnery. From the diet you need to exclude sharp, too salty, roasted and fat. Fast food and alcohol are prohibited completely.

Add to the menu you need more protein products, fiber, fruits and vegetables. Useful to drink compotes, kisins, frost, herbal teas. Every day you need to eat dairy products of low fatty. Dishes cook for couple, bake or boil.

Medications

The treatment of drug therapy is assigned only by the doctor. For treatment apply:

In addition to conservative treatment methods, use is possible. Held fees capable of restoring the affected organs of organs.



A peculiarity of folk treatment is the need for a long time to apply the same tool. Usually the course is 3-4 weeks.

Prepare boarants from plants:

  • st. John's wort;
  • sage;
  • yarrow;
  • a series;
  • tansy;
  • chamomile flowers;
  • drani root.

A tablespoon of collecting or one of the herbs insist in hot water for about 20 minutes and consume 2-3 times during the day.

Effectively combination of turmeric and garlic. This tool gives an antibacterial effect. For the preparation of therapeutic drink, one crushed garlic teeth and 1 tsp. Turmeric is mixed with boiling water (200 ml). Use twice a day before meals.

For the liver is very useful. 2/3 cup of oats are added to hot water and tomatin on fire for half an hour. After turning off the fire, the mixture is insisted for several hours. Drove the decoction three times a day before meals.

Transplantation

In circumstances, when the treatment of the affected liver is impossible, and the human life is threatened with danger, doctors resort to transplantation (transplantation) of the liver. It is necessary when:

  • congenital anomalies of the body;
  • the last stage of diffuse changes;
  • inoperable tumors (cancer and other focal formations);
  • acute.

Prediction and prevention

The forecast for diffuse changes in the tissue and the structure of the liver is primarily due to the main disease.



Since the damaged hepatic parenchyma is relatively rapidly restored, timely treatment returns the body to the former appearance and normal functions.

If the fabrics are changed by the type of steatosis, the forecast is most often favorable. The same can be said about chronic hepatitis - it is transferred to the state of remission.

Adverse - five-year survival is about 50%. Launched disease is life-threatening.

Preventive measures include general simple rules:

  • constant control over body weight;
  • rejection of harmful addictions;
  • full and healthy nutrition;
  • constant strengthening of the immune system;
  • regular visits to specialists and passage of preventive inspections.

The problems with the liver can be warned, as well as a refusal or sharp limitation of alcohol consumption.


Literature

  • Chenkov, V. G. Clinical oncology: studies. manual for the system by a postgraduate. Education doctors / V. G. Chenkov. - ed. 3rd, copy. and add. - M.: MK, 2010. - 434 C.: IL., Table.
  • Ilchenko A.A. Diseases of the gallbladder and biliary tract: manual for doctors. - 2nd ed., Pererab. and add. - M.: LLC Publishing House Medical Information Agency, 2011. - 880 s: Il.
  • Tukhtayeva N. S. Biochemistry Bilyiary Sweet: thesis for the degree of candidate of medical sciences / Institute of Gastroenterology of the Republic of the Republic of Tajikistan. Dushanbe, 2005.
  • Lithuanian, I. A. Gallgamed disease, cholecystitis and some associated diseases (questions of pathogenesis, diagnosis, treatment) / I. A. Litovsky, A. V. Gordienko. - St. Petersburg: Speclit, 2019. - 358 p.
  • Dietology / Ed. A. Yu. Baranovsky - ed. 5th - SPb.: Peter, 2017. - 1104 C.: IL. - (Series "Satellite of the doctor")
  • Pyymov, S.D. Liver disease: Guide for doctors / S.D. Village. - ed. 5th, recreation. and add. - Moscow: Medical Information Agency LLC, 2018. - 984 C.: IL.
  • Schiff, Eugene R. Introduction to hepatology / Eugene R. Schiff, Michael F. Sorrel, Willis S. Maddrey; Per. from English Ed. V. T. Ivashkin, A.O. Buyeverova, M.V. Maevskaya. - M.: Gootar Media, 2011. - 704 p. - (Series of "Schiff Diseases").
  • Radchenko, V.G. Basics of clinical hepatology. Liver disease and biliary system. - SPb.: "Publisher Dialect"; M.: "Bin Publishing House", - 2005. - 864 C.: IL.
  • Gastroenterology: Reference / Ed. A.Yu. Baranovsky. - SPb.: Peter, 2011. - 512 p.: Il. - (Series "National Medical Library").
  • Lutaya, A.V. Diagnosis, differential diagnosis and treatment of diseases of the digestive organs: Tutorial / A.V. Lutaya, I.E. Mishina, A.A. Guduhin, L.Ya. Kornilov, S.L. Arkhipova, R.B. Orlov, O.N. Aleutskaya. - Ivanovo, 2008. - 156 p.
  • Akhmedov, V.A. Practical gastroenterology: guide for doctors. - Moscow: Medical Information Agency LLC, 2011. - 416 p.
  • Internal Diseases: Gastroenterology: Tutorial for the audit work of students of 6 courses in the specialty 060101 - therapeutic case / Sost.: Nikolaeva L.V., Handogina V.T., Putintseva I.V. - Krasnoyarsk: Type. Krasgmu, 2010. - 175 p.
  • Radiology (radiation diagnosis and radiation therapy). Ed. M.N. Tkachenko. - K.: Book-Plus, 2013. - 744 p.
  • Illarionov, V.E., Simonenko, V.B. Modern methods of physiotherapy: Guide for general practitioners (family doctors). - M.: OJSC "Publishing House" Medicine ", 2007. - 176 p.: Il.
  • Schiff, Eugene R. Alcohol, Medicinal, Genetic and Metabolic Diseases / Eugene R. Schiff, Michael F. Sorrel, Willis S. Maddrey: Per. from English Ed. N. A. Mukhina, D.T. Abdurakhmanova, E.Z. Burnevich, so-called. Shopatina, E.L. Tanashk. - M.: Goeotar Media, 2011. - 480 p. - (Series of "Schiff Diseases").
  • Schiff, Eugene R. Cirrhosis of the liver and its complications. Liver transplantation / Eugene R. Schiff, Michael F. Sorrel, Willis S. Maddrey: Per. from English Ed. V.T. Ivashkin, S.V. Gauthier, Ya.G. Mysyusyuk, M.V. Maevskaya. - M.: Goeotar Media, 201i. - 592 p. - (Series of "Schiff Diseases").
  • Pathological physiology: textbook for students honey. Universities / N.N. Zaiko, Yu.V. Byzov, A.V. Ataman et al.; Ed. N.N. Zaiko and Yu.V. Bysti. - 3rd ed., Pererab. and add. - K.: Logos, 1996. - 644 p.; Il 128.
  • Frolov V.A., Drozdova G.A., Kazanskaya TA, Bilibin D.P. Demurov E.A. Pathological physiology. - M.: OJSC "Economics Publishing House", 1999. - 616 p.
  • Mikhailov, V.V. Fundamentals of pathological physiology: Guide for doctors. - M.: Medicine, 2001. - 704 p.
  • Internal medicine: Tutorial in 3 t. - T. 1 / E.N. Amosova, O. Ya. Babak, V.N. Zaitseva et al.; Ed. prof. E.N. Amosovoi. - K.: Medicine, 2008. - 1064 p. + 10 s. color incl.
  • Gaivoronsky, I.V., Nichipruk, G.I. Functional anatomy of the organs of the digestive system (structure, blood supply, innervation, lymphotok). Tutorial. - SPb.: ELBI-SPB, 2008. - 76 p.
  • Surgical diseases: tutorial. / Ed. M. I. Kuzina. - M.: Goeotar Media, 2018. - 992 p.
  • Surgical diseases. Patient Survey Guide: Tutorial / Cherniusov A.F. and others - M.: Practical Medicine, 2016. - 288 p.
  • Alexander J.F., Lischner M.N., Galambos J.T. Natural History of Alcoholic Hepatitis. 2. THE LONGTERM PROGNOSIS // Amer. J. Gastroenterol. - 1971. - Vol. 56. - P. 515-525
  • Dreyabina N. V., Aylamazyan E. K., Warinov V. A. Colestatic hepatosis of pregnant women: Pathogenesis, clinic, treatment // J. Akush. and wives. disease. 2003. №1.
  • Pazzi P., ScagliaRini R., Sighinolfi D. et al. Nonsteroidal AntiInflammatory Drug Use and Gallstone Disease Prevalence: A Case-Control Study // Amer. J. Gastroenterol. - 1998. - Vol. 93. - P. 1420-1424.
  • Marakhovsky Yu.H. Gallgame: On the way to the diagnosis of early stages // Ros. journal Gastroenterol., Hepatol., Coloproktol. - 1994. - T. IV, No. 4. - P. 6-25.
  • Higashijima H., Ichimiya H., Nakano T. et al. Deconjugation of Bilirubin Accelerates Coprecipitation of Cholesterol, Fatty Acids, and Mucin in Human Bile-in Vitro Study // J. Gastroenterol. - 1996. - Vol. 31. - P. 828-835
  • Sherlock Sh., Duli J. Liver diseases and biliary tract: per. from English / Ed. Z.G. APROSINA, N.A. Mukhin. - M.: Geotar Medicine, 1999. - 860 p.
  • Dadvani S.A., Veschev P.S., Shulutko A.M., Prudkov M.I. Cholelithiasis. - M.: Ed. House "Vidar-M", 2000. - 150 s.
  • Yakovenko E.P., Grigoriev P.Ya. Chronic liver diseases: diagnosis and treatment // Rus. honey. journal - 2003. - T. 11. - № 5. - P. 291.
  • Gardens, Alexey Cleaning the liver and kidney. Modern and traditional methods. - St. Petersburg: Peter, 2012. - 160 s.: Il.
  • Nikitin I.G., Kuznetsov S.L., Stranzhekov G.I., Petrenko N.V. Remote results of interferonotherapy of acute HCV hepatitis. // Ross. journal Gastroenterology, hepatology, coloproktology. - 1999, t. IX, No. 1. - with. 50-53.

Diffuse changes in liver parenchyma are a consequence of the development of pathological processes in the structure of the body. The identification of this state occurs in ultrasound examination and this is a reason for holding a more thorough examination, since these changes may be due to minor functional disorders and severe diseases.

Types of diffuse changes and their manifestations

The following types of disorders are allocated:

  1. Insignificant Change is observed in the initial stages of bacterial, viral inflammation or under the influence of external adverse factors.
  2. Moderate The diffuse change in the liver parenchyma appears with long-term reception of hepatotoxic drugs, alcohol and fatty food abuse.
  3. Pronounced - with hepatitis, cirrhosis, tumors, when in addition to diffuse changes in the whole body, the local destruction and edema of the hepatic tissue are revealed.

Causes of occurrence

The diffuse change in the liver parenchyma is such a transformation of the hepatic tissue, which affects not a separate area of \u200b\u200bthe organ, and the whole liver as a whole: hepatocytes are increasing in size, their density changes, the uniformity of the structure is lost. Depending on the causal factor, the dystrophy processes are predominant - infiltration of hepatic cells with fatty deposits - steatosis or on the site of dead hepatocytes are formed by a connecting tissue in the form of scars and fibrous nodes.

Diseases under which the structure of the authority changes:

Eternal nutrition. The abuse of products containing animal fats or hydrogenated oil (mayonnaise, chips, pastries, fast food, semi-finished products), leads to an increased load on the liver, which ceases to cope with the recycling of fats, and begins to postpone them into its parenchyma.

Chronic alcoholism. The intermediate product of ethanol - acetaldehyde, destructive effect on hepatic cells. Hepatocytes begin to collapse, their place occupy fat inclusions.

Inactivation of drugs occurs in the liver, many of which (antibiotics, steroid hormones, heart glycosides, cytostatics) have a hepatotoxic effect. Destructive processes under the influence of medicines lead to damage to the hepatic tissues in the form of medicinal hepatitis and a decrease in the functional activity of the liver.

Adverse ecological situation. People living near large industrial industries, lively car trails increase the risk of liver damage. With prolonged arrival of harmful substances in the body, metabolic processes in hepatocytes slow down, toxins accumulate, which causes the development of various diseases.

Psycho-emotional overload. During stress from adrenal glands, a hormone adrenaline is thrown into the blood. In large concentrations, it adversely affects the function of hepatocytes.

Symptoms of liver parenchyma changes

If the changes in the liver occur by the type of fatty hepatosis develops a compensatory increase in the organ - hepatomegaly.

In childhood, along with the reasons that cause violations in the structure of the liver in adults, genetically determined pathology is often published:

  • defects of enzymes, violation of protein metabolism.
  • congenital fibrosis, multi-storey, liver cirrhosis.

Useful video

Why diffuse liver changes can be found from this video.

Ultrasound signs of liver pathology

Normally, the photo can be seen that the structure of the liver is homogeneous with a challenged grain characteristic. Ultrasound, not reflected from the surface, it flows freely, echogenicity of weak intensity. The sizes and form of the organ are not changed.

Pathological processes in the liver are sclerotic, hypertrophic or dystrophic character.


Echographic signs of diffuse liver changes:

At greed hepatosis

  • echogenicity is significantly increased;
  • the form of the organ is not changed, the contours are smooth, fuzzy;
  • sometimes there is an increase in size;
  • the structure of parenchyma is uneven heterogeneous;
  • deletion of vascular pattern;
  • foci of reduced echogenicity are found.

With a combination of fatty infiltration with fibrous changes (with hepatitis, cirrhosis), an ultrasound increase in the echogenicity of the surface layers of parenchyma is combined with the extinction of echo signal in deep departments.

In chronic hepatitis

With cirrhosis of the liver

  • the form of the organ may change, the contours become uneven, the surface is buggy;
  • hepatomegaly;
  • smoothed vascular pattern;
  • expansion of a gorgeous and spleen veins;
  • echogenicity is significantly increased.

Diffusedly focal liver changes are formed by increasing the pathological process, in which the zones of increased echogenicity (foci of fibrosis, sclerosic walls of vessels and bile ducts) alternate with the regeneration sites and islands of normal tissues that have medium and low echogenicity.


Many pathological processes in the liver tissue for a long time flow without symptoms and is usually diagnosed only according to the ultrasound. Often patients are interested in what a diffuse change in the liver parenchyma and that should be taken further.

The liver belongs to the organ that is capable of regeneration. Therefore, in the diagnosis of diffuse changes, together with drug treatment, a large role in the recovery is given to the elimination of factors that negatively affect the rehabilitation processes (refusal of alcohol, oily fried food, smoking).

Moderate diffuse liver changes, as well as pronounced, are not considered by doctors as a separate disease. They only indicate that the parenchyma swells and increases in size.

The processes occurring with the tissues of the body under consideration may be of different nature. Distinguish, in particular:

  • hypertrophic;
  • swelling;
  • dystrophic;
  • sclerotic.

They may develop and by type of hepatosis.

In order to proceed with treatment, first of all, it is necessary to identify and diagnose the underlying disease provoked the changes in question.

General reasons

The pathology under consideration is often found in people:

  • abusing alcohol;
  • smokers;
  • noncommunicating healthy nutritionals.

Contributes to the development of changes in the structure of the body also:

  • genetic predisposition;
  • bad environmental situation in the region of residence;
  • long taking antibiotics and some other drugs.

Damages the parenchyma to no less:

  • disorder of liver metabolism;
  • infection with its viruses;
  • hepatitis autoimmune;
  • cirrhosis;
  • jumping or weight loss.

Not only adult people can face with a similar problem, but also children. Most often in the latter case, diffuse changes are a consequence of the jaundice transferred before the topics.

General symptoms

The problem lies in the fact that the state under consideration in the overwhelming majority occurs without any symptoms.

Very rarely observed such signs:

  • non-essential pain syndrome in the right side of the body under the edges;
  • it is felt there the same severity;
  • yellowes the skin around the eyes and their mucous.

Sometimes pain irradiates to the right forearm.

The culprit of diffuse changes is often sugar diabetes. The liver in this case increases in all shares, and on the echoogram still detect:

  • heterogeneity of the structure;
  • the smoothness of the vessels;
  • increased echogenicity of tissues with noticeable attenuation in the depths of the organ.

Diffuse changes affecting other liver, also other organs

As is known, all organs involved in the digestive process are connected into a single system with ducts. And this, in turn, means that a functional disorder that arose in one of them will result in the operation of another.

The state of the pancreas is often worsening due to:

  • metabolic disorders;
  • infections;
  • diseases of vessels.

It often suffers from steatosis, when dead tissues are replaced by fat. The undoubted provocateur also performs pancreatitis both acute and chronic. The considered destructive processes sometimes affect, in addition to the liver:

  • spleen;
  • kidney.

Pronounced and moderate changes

Changes in any strength almost always precedes the impact of negative external factors. The depth of destructive lesion is determined by the level of Parenhim's swelling.

The reasons contributing to the launch of a dangerous process are several:

  • harmful (mostly fatty food);
  • poisoning;
  • infection with different viruses.

If it is not possible to identify the disease in time, then the treatment will allow to reverse it. First of all, it is required to eliminate the effect of harmful factors. Serious disorders of liver functions require blood purification with special procedures. The removal of alcohol decay products from it and other hazardous substances will reduce the load on the body and increase the effectiveness of treatment.

With moderate changes, the course is also useful will be a course reception of multivitamine preparations.

Diagnostics

The most accurate diagnostic method is ultrasound. But this type of diagnosis in the overwhelming majority does not allow to identify primary pathology, therefore a number of laboratory studies are also required.

Analyzes are held:

  • blood on biochemistry and general;
  • urine.

In controversial situations, biopsy is prescribed. Helps determine the cause of CT and MRI.

The presence of diffuse changes are the following signs:

  • high density of liver structures over its entire surface;
  • combining vessels.

Treatment

The effectiveness of therapy largely depends on the installation of the exact reason that has running the change process. Almost any pathology of the internal organs as a result leads to minor or moderate diffuse disorders.

Accelerate the recovery process helps diet number 5. The patient needs to also refuse tobacco and alcohol. If the problem lies only in the wrong lifestyle, it will be quite enough.

Hepatoprotectors created on the basis of vegetable raw materials are also prescribed. The most efficient folk remedies include:

  • plum juice;
  • chicory (decoction of the root);
  • pumpkin baked with honey;
  • calendula;
  • chamomile;
  • mint;
  • distracy.

All dishes need to be used in moderately warm. Food fractional - the daily rate of products is divided into 5 or 6 parts. Prepare food in a double boiler or oven without fat, spices and spices. Salts use the minimum amount - no more teaspoon per day.

Exclude from the diet:

  • fat bird (duck, goose), meat (pork, lamb), fish;
  • eggs in any form;
  • sub-products all;
  • rich broths, including mushroom;
  • fresh bread and sdoba;
  • kvass and okroshka;
  • milk and products with high fat content;
  • canned;
  • smoked;
  • sausage products (even boiled);
  • sweets with fat cream;
  • chocolate;
  • ice cream;
  • garlic;
  • sorrel;
  • mushrooms;
  • spinach;
  • radish.

At the same time, it is allowed to eat:

  • natural honey;
  • jam;
  • furnishing bread;
  • pies and buns cooked in the oven;
  • nonxal fruits and berries;
  • weak black tea and coffee (preferably with milk);
  • freshly squeezed juices;
  • vegetable puree;
  • omelet from some proteins;
  • vegetable soups;
  • molkproducts are skimmed;
  • lachion (no visible fat paste) meat.

We recommend to read

Top