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After the operation, during which an embryo was implanted in the woman's body, the expectant mother may not feel any significant changes, but in reality, continuous metamorphoses occur in the body at this moment. The result of these processes is pregnancy, that is, the attachment of the embryo to the uterus. This moment will not pass unnoticed for a woman.
First of all, medical workers puncture the woman and take the eggs. Next, the woman's eggs, together with the processed partner's sperm, are placed in a special incubator, where they are cultivated for a day. On the first day, doctors can only give a preliminary assessment of the process. On the second day, usually the egg, fertilized by the partner's sperm, is already turning into an embryo. At this stage, specialists can choose the most "promising" eggs.
After this, at least four days must pass before a new stage begins, in which the most important process is carried out - directly transfer to the embryo in the uterus. 
On the same day, doctors take future mother blood for tests on the level of progesterone and estradiol. These data will be needed in the near future in order to be able to prescribe support for the initial stage of gestation. In addition to tests, you will need to undergo an ultrasound examination to obtain objective information about the condition of the ovaries and the uterine cavity. 
The condition of the ovaries after stimulation is quite specific, since the procedure provokes the appearance of cysts of the corpus luteum. This condition will not cause any inconvenience to the expectant mother, since this is a natural reaction of the body. In some cases, a complication occurs - ovarian hyperstimulation syndrome, however, an experienced doctor can easily identify the pathology. 
Determination of the day for implantation
The choice of a suitable day for the procedure is influenced by many factors, including:
- woman's age;
- the number of eggs;
- the rate of development of embryos;
- the number of transfer operations carried out earlier;
- the patient's history.
Period after surgery
After the IVF procedure, over the next fourteen days, you should not take any deviation from the normal state as a sign of pregnancy. At this stage, the woman may feel slightly nauseous, weak and dizzy, but this does not guarantee that the operation was successful. The exact result can be found out only after tests for chorionic gonadotropin are taken. 
Many women immediately after implantation rush to buy pregnancy tests, but their result is also not indicative. Many experts strongly do not recommend getting involved in such experiments, so as not to be disappointed in vain. Sometimes expectant mothers simply do not have the patience to wait for the outcome of two weeks. It should be understood that a negative pregnancy test does not mean that the embryo transfer procedure was unsuccessful. 
How to prevent OHSS
All that is required from a woman before donating blood is an attentive attitude to her health. We have previously discussed that OHSS may develop after surgery. If a woman turns to a reproductive specialist in time, then difficult consequences can be avoided. 
Among the clinical manifestations of ovarian hyperstimulation syndrome, one can note:
- bloating, abdominal discomfort;
- pain in the ovaries or uterus;
- persistent migraines;
- various visual defects - the appearance of "flies", fuzziness;
- puffiness.
Usually, OHSS develops slowly enough that it can be managed with the help of a well-chosen course of treatment. The amount of time spent recovering from OHSS also depends on the support program chosen.
Support Program
In most cases, within seven days after implantation, doctors take blood to determine the correct support program. It includes qualified control over the processes occurring in a woman's body and the prevention of possible complications. When doctors feel that there is a danger of pathology, they take blood samples every few days. 
A sign that the selected support program is not suitable for the expectant mother is bloody issues. Some women mistake them for menstruation, but in reality this is evidence that the level of hormones in the woman's body is disturbed. Therefore, doctors should change the amount of drugs that the expectant mother uses. At the slightest suspicion, you should immediately contact a reproductologist who can adequately assess the condition of the woman.
Physical exercise
If before the procedure, mommy's life was not particularly dynamic, then in the first fourteen days nothing will change significantly. Experts recommend not to get involved in fitness, running and other sports activities during this period. This is due to the increase in the size of the ovaries. For the same reason, a woman after implantation does not want to have sex - this may be accompanied by painful sensations. 
In no case should you go to extremes and lie in bed from morning to evening. After the embryo transfer, the immobility of the woman has only negative effect: blood circulation worsens. The result of this is a decrease in the flow of oxygen to the embryo. 
The best and most adequate solution for spending time in the first two weeks after implantation is quiet leisure. It is best to walk more in the air, get out into nature. It is better to stop smoking and drinking alcohol.
It is very important to avoid stress, as any conflict situation can negatively affect the program.
Diet after embryo transfer
In the first fourteen days after the procedure, there is no need to radically change the menu. As in other periods, it is necessary to eat only healthy foods. It is important that the diet is varied and regular. 
A special diet is usually prescribed if something went wrong in the woman's body after the embryo transfer. With ovarian hyperstimulation syndrome, it is not recommended to eat foods high in salt. In no case should you go on a hunger strike, as this will be an extra burden for a weakened body. 
A woman is required to consume a sufficiently large amount of liquid - at least one and a half liters. However, it is best to drink pure water - not mineral and not carbonated. Juices that provoke gases are also not suitable for this period.
Of course, there are situations when reproductologists decide that a woman's menu should be changed. In such situations, you should not neglect the recommendations of a specialist. Most often, changes in the diet involve eating a lot of greens and limiting the use of salt already mentioned above.
Sedatives 
Often, during the period of waiting for results, women's mood deteriorates very much. During this long period, you can help your body cope with stress. Most often, experts recommend taking soothing decoctions of herbs and valerian. The use of medications must be agreed with your doctor without fail.
Most women complain of fever after embryo transfer. These experiences are quite justified, because colds in the first fourteen days after the procedure can have a negative impact on the development of the embryo.
Experts say that in this case there is no reason to worry, as this is normal in this condition. However, it is necessary to monitor body temperature with special attention. It is best to record these indicators every day in a notebook so that you can assess the state of the body. If the temperature does not rise above 37.5, then the embryo is fixed normally.
except elevated temperature, there are several more signs that indicate that a woman will soon be pregnant:
- swelling of the mammary glands;
- change in color of the nipple;
- acute reaction to various odors;
- pulling sensation in the lower abdomen.
According to statistics, about 40 percent of all cases of using the IVF method ends with a positive result. Repeated implantation attempts are guaranteed to lead to pregnancy.
Video - Embryo Transfer
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Instruction
After the in vitro fertilization procedure, women begin to listen to their body, look for signs, confirmation in dreams and signs, and sometimes fall into severe depression without finding them. Some ladies control their every breath and movement, afraid to interfere with the birth of a baby. All this, oddly enough, only prevents the onset of pregnancy. For successful IVF, doctors give a number of recommendations.
After IVF, try to drink as much liquid as possible, at least two liters a day, eat protein products(fish, meat, nuts, dairy products). The diet also welcomes sour-milk products, herbs and dried fruits. Avoid foods that can cause flatulence (grapes, fresh fruit, carbonated drinks). Do not get carried away with buns and potatoes, as they are difficult for digestion. Give up alcohol and do not abuse coffee, strong tea.
Ensure good blood supply to the uterus. Constant lying is not the most suitable way for this. Walk in the fresh air as often as possible, walking will help improve blood circulation, ensure blood flow in the pelvic region and uterus. While lying down, it is recommended to put pillows under your feet, this position contributes to the flow of blood to the pelvic organs and relaxation of the uterus.
Provide yourself with a calm state of mind and a positive attitude. Read interesting good books, listen to pleasant music, go to museums and theaters, watch your favorite films and TV shows. Be in nature more often, communicate with nice people. Believe in the best and enjoy life. It is also worth noting that few women manage to get pregnant on their first attempt after IVF. It is quite likely that you will have to go through this procedure again.
After the transfer itself, nothing may appear outwardly for the next two weeks, but constant and continuous processes are going on in the uterus, which should culminate in the attachment of the embryo to the wall of the uterus, that is, the beginning of pregnancy. The very moment of attachment "implantation"; it is impossible to feel, no subjective signs point to it until the 14th day after the transfer, until the day of donating blood for hCG. Nausea, dizziness, breast swelling, drowsiness, absence of premenstrual symptoms, etc. - nothing is objective, nothing should be emphasized as an argument for or against.
What will happen after the embryo transfer
After puncture and egg collection, 4–5 days pass, and a new stage of the IVF protocol begins - the transfer of embryos into the uterine cavity. The transfer itself takes 2-5 minutes, but on the day of the transfer, blood is also taken for the hormones progesterone and estradiol - this will be needed in the near future. Indeed, after the transfer, most modern IVF clinics provide support for the initial period of pregnancy, and this support can be objectively assigned only on the basis of data on the level of hormones.
Of course, ultrasound is also mandatory - what is the condition of the uterus and ovaries? The thickness of the endometrium is very important. What do the ovaries look like (and, accordingly, how will they function)? The type of ovaries is specific, their stimulation leads to the formation of large cysts in place of the follicles - but this is not a painful condition, but a transient, normal and inevitable after hormonal exposure. In extremely rare cases, at this stage, an experienced doctor can catch signs of impending ovarian hyperstimulation syndrome (OHSS) - a rare but formidable complication of IVF.
After the transfer itself, nothing may appear outwardly for the next two weeks, but constant and continuous processes are going on in the uterus, which should culminate in the attachment of the embryo to the wall of the uterus, that is, the beginning of pregnancy. The very moment of attachment (implantation) cannot be felt. Nausea, dizziness, breast swelling, drowsiness, absence of premenstrual symptoms, etc. - nothing is objective, nothing should be emphasized as an argument for or against. The exact answer to the most important question cannot be obtained until the 14th day after the transfer, when blood is donated for chorionic gonadotropin (CG).
In the same way, pregnancy tests are not indicative until the 14th day. Although doctors advise their patients not to have tests to avoid disappointment, most women start having urine tests on the 8th to 10th day after the transfer. Statistics show that if the test result is clear, then the probability of pregnancy is high. But if the test is weakly expressed or completely negative, then the chances of pregnancy still remain quite high. That is, we can say that a positive test even before the 14th day is a good sign, and a negative test is not always an indicator of failure.
Two weeks before donating blood for HCG, a woman needs to actively monitor her condition. First, it is very important on the most early stage catch signs of ovarian hyperstimulation syndrome (OHSS). The reason for an immediate appeal to a reproductologist can be bloating, pain in the uterus and ovaries, unusual swelling, headache for no apparent reason, blurred vision in the form of "flies", fog, blurred images. OHSS develops gradually, and when adequate treatment is carried out, it disappears quickly enough. Therefore, it is better not to start its detection and treatment. In addition, if a woman develops OHSS even to a very mild degree, then the support program needs to be changed.
For high-quality support, blood for hormones is taken a week after the embryo transfer and on the 14th day - simultaneously with the analysis for hCG. In most cases, this frequency is sufficient to adequately control ongoing processes and prevent complications. But in special cases, tests can be done every 3-4 days.
The need to change the support may be indicated by spotting from the vagina. This is by no means premature menstruation, but an indicator of a violation of the ratio of hormones in a woman's body, which requires correction of doses of drugs. Therefore, you need to contact your reproductologist immediately.
How to behave after an embryo transfer
Your life will not be limited if you did not have a penchant for extreme sports before the program. Physical activity must be limited, fitness, running, power loads in the gym should be excluded - enlarged ovaries can respond with soreness. sex life is not excluded, but can be limited at the request of a woman: because of the pain associated with an increase in the size of the ovaries, and fear for the fate of pregnancy.
On the other hand, one should not prescribe bed rest for oneself: immobility leads to a deterioration in blood circulation and reduces the flow of oxygen to the uterus and fetus. This can play a negative role in the implantation processes.
In a word, the optimal daily routine for two weeks after the transfer is a quiet, calm pastime in the fresh air, walks in nature rather than shopping, smoking restriction (if you still smoke), avoiding stressful situations with others.
There will also be no special changes in the diet. Nutrition should be healthy, varied, regular. Only if the doctor suspects the development of OHSS, he can prescribe special diet, for example, with salt restriction. It is not necessary to start fasting or changing the usual diet these days: this is an extra burden on the body. You need to drink enough liquid - 1-1.5 liters per day, while avoiding mineral and carbonated water, as well as gas-forming juices (primarily grape juice).
If a reproductologist recommends changing your diet, listen to his advice. Restriction of salt, excess water, consumption of greens are usually part of the prevention and treatment of OHSS.
Two weeks is a long time, the tension of waiting is a difficult test for the psyche. If your mood worsens, sleep is disturbed - do not neglect simple sedatives. Valerian in any form, sedative fees - all this can be used to keep calm in anticipation of a positive result. Any others sedatives it is better to discuss with your doctor - how safe they are for a possible pregnancy.
In a word, these two weeks are both very significant and very common - do not make a horror story out of them, be calm.
/ Useful information
16.05.2011
The long-awaited day of embryo transfer has arrived. Behind the long-term treatment, endless examinations, taking hormones, bruises from injections, worries about the endometrium, follicles, monitoring, puncture ... Everything. You can breathe out. The job is done, it remains to wait. Do you need to relax? Is there life after embryo replanting or is everything just beginning? What can and cannot be done? How to protect yourself from mistakes and protect such a tiny, but already dear baby? We learned about this in a conversation with Elena Popenko, Candidate of Medical Sciences, obstetrician-gynecologist-endocrinologist, reproductologist at the Mercury International Center for Reproductive Medicine.
- Elena Vasilievna, why is the period “after embryo replanting” dangerous? Or can you relax and go about your business, continue to lead a normal life?
"After Embryo Transfer" Doctors don't usually say that. We have another term "after embryo transfer". But if you understand it that way, then you can do it that way too. We have many cases where a very short period of time passes, and patients after embryo transfer digging potatoes in the garden; running around the shops with bags of groceries to feed a tired husband from work; they are engaged in creativity - they glue wallpaper and make repairs at home in order to do something during the sick leave. And then they end up in the hospital and can no longer save what they have been treated for so long. I would like to address such patients:
"WOMEN! Feel loved, tender and weak! These men should take care of you now! Carry on your hands, carry food, take out the trash and equip housing! Let it fall on their shoulders. Let them be strong and courageous! You have been waiting for this wonderful event for so many years, you have become pregnant. After replanting the embryos, think about yourself and the future baby.”
Time after embryo transfer - a really dangerous period: the embryos have not yet established themselves, they just got into an environment that is alien to them and settle down in a new place. Usually if you move to new house- you don’t like one thing, then you need to rearrange the other, then hang the curtains, then paint the walls, then open the window. So are babies. In order not to disturb them, it is advisable to lie down at home, sleep, and rest on the day after embryo transfer. And observe specially developed rules of conduct.
What to do “after embryo replanting” so as not to harm yourself and the baby?
- Mandatory bed rest. Especially the first 10 days after embryo transfer. You can get out of bed, but in order to visit a doctor. These first days are very important as the implantation of the embryos will take place. It is known that blastocysts are implanted on the first day (the day of transfer is not considered), and blastomeres in the first 2-4 days.
- Sexual rest up to 3 months. It is very important. Up to 12 weeks, the threat of miscarriage is relevant.
- Follow the instructions of the attending physician. Now any information is available, on the Internet you can find any recommendations. But remember. Only the attending physician is aware of your problems and treatment, only He can provide effective assistance at the right time
- After embryo transfer watch your diet. You need to eat protein foods. You can cook on vegetables, meat, steamed fish, in the oven, on fire, boiled. It is advisable to use milk, dairy products, cook cereals, you can drink juices, fruit drinks, rosehip decoctions, green tea.
- After replanting you need to measure the basal temperature every day at the same time and mark it in a notebook. This should be done without getting out of bed, at the same time with a mercury thermometer. If the basal temperature figures are below 37 degrees C for 3 days, urgently call the center for consultation with specialists. We have a 24/7 phone, so don't be shy. Even at night, we have people on duty on the phone who will give advice or contact the attending physician.
Found this, I hope it's helpful. I wish you all GOOD LUCK.
“Lifestyle after transfer
1. In no case should you have sex after the puncture (that is, between the puncture and the transfer), although doctors allow it.
2. Immediately after the transfer, when you were brought on a gurney and reloaded onto the bed, you need to completely relax, put your legs straight or slightly apart from the side (as convenient), and your arms along the body. IN NO EVENT SHOULD YOU PLACE YOUR HANDS ON YOUR HEAD (many people like to lie down so much in life), or fidget on the bed (such as “cold-hot-fix the blanket-take a mobile phone, etc.). If something interferes or is uncomfortable for you, then ask other girls (who have not yet transferred embryos) to give you, correct, tuck in the blanket, etc. That is, you can’t strain any muscles at all for ABSOLUTELY at least an hour (and preferably two). No more, because you want to write, but you can’t tolerate this business at all. This is exactly the time you will spend on a drip (if immediately after the transfer) and chatting with other girls.
3. Well, I won’t write about the mood - it’s clear that you need to aim for success and remain calm.
4. Discuss the situation with the doctor in advance, if you start to have pain, then how to eliminate them (you cannot tolerate it). Pain occurs in those whose periods are usually painful. They are the same as during menstruation, but can be stronger. And they cannot be tolerated. The most harmless remedy is no-shpa. But, unfortunately, it does not help everyone. Everything else is more harmful. But in the period of 3-7 days (the first day - the day of the puncture), you can take almost everything (even analgin and other GINS). But you need to discuss this with your doctor. Candles with papaverine help well (absolutely harmless), but, again, not for everyone
5. Further, in the period of 3-7 days, maintain a semi-bed rest. No stress, no housework. Walk in the yard on a bench (I quietly went out into the yard with a book, sat on the bench for a couple of hours - and back to bed). There are no dog walks, shops, etc. Forget about all this. After the 7th day, you can already start moving slowly. But everything is very, very moderate.
6. Household chores for many do not disappear. Therefore, for me, for example, my husband bought a bar stool. I still do everything sitting on it at the cutting table - I wash my dishes and cook food.
7. After the transfer, immunity always falls. Therefore, if you feel that you suddenly get sick (autumn-winter, especially), immediately put a dropper with immunoglobulin. You will immediately feel completely healthy (at this time, none of the strong drugs can be taken).
8. Almost everyone has the feeling that their period is about to begin. In no case do not get upset. This can happen even with a successful attempt, this is not an indicator. We must wait for the results of hCG and then everything will be clear. And not a minute earlier.
How to behave and what rules to follow after the transfer of embryos into the uterine cavity.
Embryo transfer is the final procedure of infertility treatment by in vitro fertilization. The resulting embryos are placed into the uterine cavity with the help of a special conductor. The cells and the amount of medium in which they are transferred are very small and therefore never fall out and flow back out, there is no need to be afraid of this. In the future, they either “take root” or not, however, after embryo transfer, we recommend bed rest for 3 hours and half-bed rest (lie more, move only when necessary, avoid long journeys if possible) for 2-3 days. From the 4th day you can lead a normal life, with the exception of the following: - lifting weights over 2 kg, jumping, running; - live sexually until the next menstruation; - take hot baths and wash in the bath (you can take a shower); - it is desirable to avoid hypothermia and overheating, to beware of colds; - without special instructions (which can only be given by a doctor) to take medications; - avoid all sorts of conflicts as much as possible; - it is desirable to avoid difficult stools, but if this bothers you, you can take laxatives in moderation (preferably Duphalac).
Recommended: Leading a normal, but more relaxed lifestyle, walking more. You can sleep in any position convenient for you (on your back, stomach, etc.). If you live in another city, you can go home 4-5 days after the embryo transfer by any means of transport. Measure your basal temperature daily and mark it on your chart.
Diagnosis of pregnancy. 14 days after the embryo transfer, in the absence of menstruation, a urine test “for pregnancy” should be performed or a blood test for hCG should be taken. A positive result and more indicates the onset and progression of pregnancy, but does not exclude the possibility of the onset ectopic pregnancy, therefore: 21 days after the embryo transfer (in the absence of menstruation), it is necessary to appear for an ultrasound examination, in which you can accurately determine the location of the fetal egg. The gestation period is calculated approximately from 3-7 days from the start of stimulation with menopausal gonadotropic drugs (humegon, or menogon, or pergonal, or puregon, etc.), or 7-10 days before the transfer of embryos into the uterine cavity. With ultrasound fertilized egg begins to be clearly visualized only 3 weeks after embryo transfer. If menstruation does come, stop measuring temperature, taking medication and return to normal life. Most often, the treatment does not change the duration of your menstrual cycle, but sometimes menstruation occurs earlier or later by 1-3 days. A low hCG value often indicates a non-developing pregnancy, but it is better to donate blood for hCG again in one to two days. In case of failure, a second course can be carried out in the next cycle or after resting 2-3 menstrual cycles, and if some of your embryos were frozen, then you can transfer them right in the next cycle.
“Medications allowed during pregnancy.
After the transfer, the house should be:
No-shpa in tablets and / or in ampoules,
Papaverine in candles
Progesterone oil solution 2.5% 1 ml in ampoules,
Dicynon in ampoules (respectively, syringes),
Tranexam 250 mg tablets
Magne B6/Magnelis tablets
support drugs (Utprozhestan / Duphaston, Proginova / Divigel / Crinon, etc.) are in abundance.
If you start smearing in the protocol or in the first weeks of pregnancy:
A very large percentage of IVF pregnancies is accompanied by bleeding of varying severity, especially in the first 12 weeks, without negative consequences for the baby. If discharge occurs, call your doctor.
Do not panic, drink Valerian or Persen, lie down.
If you don't call your doctor:
Increase support: add Proginova 1 t. and an injection of Progesterone in oil 2.5% 1 mg, cancel Thrombo-Ass / Aspirin Cardio and Fraxiparine / Clexane.
If it smears brown or pale pink, then add 1 shot of Progesterone oil solution 2.5%, 1 ml per day until it stops smearing.
- if it smears pink - 1 tablet of Tranexam 250 mg 3 times a day, but not more than three days + add 1 injection of Progesterone oil solution 2.5%, 1 ml per day until it stops smearing.
- if there is scarlet blood - on the first day, 3 injections of Dicinon (every 4 hours for an injection). Further, if the blood persists, 1 injection per day + 2 Tranexam tablets per day, but not more than three days. + add 1 injection of Progesterone oil solution 2.5%, 1 ml per day + 1 t. Proginova / 1 sachet of Divigel per day until it stops smearing. If possible, give IV magnesium (once a day) or take it in tablets 1x3 times a day.
- if there is heavy bleeding - CALL AN AMBULANCE!!!
And lie down!"
What happens to embryos after transplantation?
What and when happens to three-day embryos:
1DPP … Embryo grows and develops
2DPP…embryo reaches blastocyst stage
3DPP… The blastocyst hatches from the shell on this day
4DPP… The blastocyst attaches to the wall of the uterus
5DPP… Implantation begins, blastocyst begins to implant into the uterine wall
6DPP… The implantation process continues and the morula grows deeper into the uterine wall
7DPP... Morula is fully implanted in the uterus and has a placenta and germ cells.
8DPP... Placental cells begin to produce hCG in the blood
9DPP… hCG gets stronger as the fetus develops
10DPP… More HCG is produced as the fetus continues to develop
11DPP… HCG levels are high enough to show on a blood test
Five days or blastocysts:
1DPP… The blastocyst hatches from the shell on this day
2DPP… The blastocyst attaches to the wall of the uterus
3DPP… Implantation begins, blastocyst begins to implant into the uterine wall
4DPP… The implantation process continues and the morula grows deeper into the uterine wall
5DPP... Morula is fully implanted in the uterus and has a placenta and germ cells.
6DPP... Placental cells begin to produce hCG in the blood
7dp…hcg gets stronger as the fetus develops
8DPP… More hCG is produced as the fetus continues to develop
9DPP… HCG levels are high enough to show on a blood test As you and I know, the day of the transfer is considered as 0DPP.
To all the fulfillment of our greatest desire - three-digit hCG, a speedy pregnancy and healthy children !!!
