Indomethacin capsules instructions for use. The drug indomethacin. Use during pregnancy and lactation

Is the drug "Indomethacin" (tablets). Due to its anti-inflammatory, analgesic and antipyretic effects, it is used to treat inflammatory diseases, eliminate pain, reduce swelling and restore joint mobility.

Description of the drug

The main active ingredient of the drug is indomethacin, which belongs to the derivatives of indoleacetic acid. The instruction describes the tablets inside the package of the drug "Indomethacin" as elements with a protective enteric coating, which allows the active substance to be released in the intestine, bypassing the stomach. The tablets are round, biconvex in shape, covered with a light brown shell on top.

Tablets come in several dosages: 25 mg, 50 mg and 100 mg of indomethacin. Available in packs of 10 or 40.

All dosage forms

In addition to tablets, there are other forms of the drug "Indomethacin" for oral use, for example, capsules with prolonged action with a dosage of 75 mg. For rectal administration, suppositories with a dose of 50 mg are used. For external use, an ointment of 5% and 10% and a gel of 3% were created.

Mechanism of action

Long-term use of the drug "Indomethacin" (tablets) does not exclude adverse reactions associated with sleep disturbance, dizziness, peripheral neuropathy, headache, agitation, irritability, fatigue. They are characterized by clouding of the cornea, conjunctivitis, hearing loss, tinnitus, high blood pressure, edema.

In this article, you can read the instructions for using the drug Indomethacin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Indomethacin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Indomethacin analogues in the presence of existing structural analogues. Use for the treatment of inflammation in rheumatology and gynecology in adults, children, as well as during pregnancy and lactation.

Indomethacin- non-steroidal anti-inflammatory agent, a derivative of indoleacetic acid. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is associated with inhibition of the COX enzyme, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.

Suppresses platelet aggregation.

When administered orally and parenterally, it helps to relieve pain, especially joint pain at rest and during movement, reduce morning stiffness and swelling of the joints, and increase range of motion. The anti-inflammatory effect develops by the end of the first week of treatment.

When applied topically, it eliminates pain, reduces swelling and erythema.

When applied externally, it also helps to reduce morning stiffness and increase range of motion.

Pharmacokinetics

After oral administration, indomethacin is rapidly absorbed from the gastrointestinal tract. Metabolized in the liver. It undergoes enterohepatic recirculation. Excreted in the urine - 60% in the form of unchanged substance and metabolites, and with feces - 33% mainly in the form of metabolites.

Indications

For systemic use:

• pain in the spine;
• neuralgia;
• myalgia;
• traumatic inflammation of soft tissues and joints;
• rheumatism;
• diffuse connective tissue diseases;
• dysmenorrhea.

As an aid in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

For topical use:

• prevention of the inflammatory process during surgical interventions for cataracts and in the anterior segment of the eye;
• inhibition of miosis during surgery.

For outdoor use:

• articular syndrome (including rheumatoid arthritis, arthrosis or osteoarthritis, ankylosing spondylitis, gout);
• pain in the spine;
• neuralgia;
• myalgia;
• traumatic inflammation of soft tissues and joints.

Release form

Candles for rectal use 50 mg and 100 mg.

Tablets, coated, soluble in the intestine 25 mg.

Capsules 25 mg and 50 mg.

Ointment for external use 10%.

Gel for external use 5%.

Instructions for use and dosing regimen

Set individually, taking into account the severity of the course of the disease. For adults, when taken orally, the initial dose is 25 mg 2-3 times a day. With insufficient severity of the clinical effect, the dose is increased to 50 mg 3 times a day. Dosage forms of prolonged action are used 1-2 times a day. Maximum daily dose: 200 mg.

When the effect is achieved, treatment is continued for 4 weeks at the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg. Taken after meals.

For the treatment of acute conditions or the relief of an exacerbation of a chronic process, 60 mg is administered intramuscularly 1-2 times a day. The duration of the / m administration is 7-14 days. Then indomethacin is used orally or rectally, 50-100 mg 2 times a day, while the maximum daily dose should not exceed 200 mg. For maintenance treatment, 50-100 mg is used rectally once a day at night.

For local use in ophthalmology, the dose, frequency and duration of use are determined individually.

Externally applied 2 times a day.

Side effect

• nausea, vomiting;
• anorexia;
• pain and discomfort in the abdomen;
• constipation or diarrhea;
• erosive and ulcerative lesions;
• bleeding and perforation of the gastrointestinal tract;
• intestinal strictures;
• stomatitis;
• flatulence;
• bleeding from the sigmoid colon or from the diverticulum;
• dizziness;
• headache;
• depression;
• feeling tired;
• anxiety;
• fainting;
• drowsiness;
• convulsions;
• peripheral neuropathy;
• muscle weakness;
• involuntary muscle movements;
• sleep disorders;
• mental disorders (depersonalization, psychotic episodes);
• paresthesia;
• swelling;
• increase in blood pressure;
• tachycardia;
• pain in chest;
• arrhythmia;
• arterial hypotension;
• congestive heart failure;
• hives;
• erythema nodosum;
• skin rash;
• hair loss;
• a sharp drop in blood pressure;
• anaphylactic reactions;
• angioedema;
• pulmonary edema;
• leukopenia;
• DIC syndrome;
• hearing impairment;
• deafness;
• interstitial nephritis;
• impaired renal function;
• hyperglycemia;
• glycosuria;
• vaginal bleeding;
• hot flashes;
• increased sweating;
• nose bleed;
• enlargement and tension of the mammary glands;
• gynecomastia;
• the formation of an infiltrate, abscess (with local and intramuscular injection);
• itching, redness, rash at the site of application.

Contraindications

• hypersensitivity to indomethacin;
• erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
• "aspirin triad";
• hematopoietic disorders;
• severe violations of the liver and / or kidneys;
• severe forms of chronic heart failure, arterial hypertension, pancreatitis;
• 3rd trimester of pregnancy;
• childhood up to 14 years;
• for rectal use: proctitis, recent bleeding from the rectum.

Use during pregnancy and lactation

Indomethacin is contraindicated in the 3rd trimester of pregnancy. In the 1st and 2nd trimesters of pregnancy, as well as during lactation ( breastfeeding) is not recommended.

Indomethacin is excreted in breast milk in small amounts.

special instructions

Use with caution in elderly patients, as well as in diseases of the liver, kidneys, gastrointestinal tract in history, with dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after major surgical interventions, with parkinsonism, epilepsy.

With indications in the anamnesis of allergic reactions to NSAIDs, they are used only in urgent cases.

During the period of treatment, systematic monitoring of the function of the liver and kidneys, the picture of peripheral blood is necessary.

Do not use indomethacin concomitantly with diflunisal.

With the simultaneous use of indomethacin with lithium preparations, the possibility of symptoms of the toxic effects of lithium should be borne in mind.

When applied topically, do not apply to the wound surface of the skin, and avoid contact with the eyes or mucous membranes.

Influence on the ability to drive vehicles and control mechanisms

During the treatment period, you should refrain from potentially dangerous species activities related to the need to concentrate and increased speed psychomotor reactions.

drug interaction

With the simultaneous use of indomethacin can reduce the effects of saluretics, beta-blockers; enhance the effects of indirect anticoagulants.

With the simultaneous use of indomethacin and diflunisal, there is a risk of severe bleeding from the gastrointestinal tract.

With simultaneous use with probenecid, an increase in the concentration of indomethacin in the blood plasma is possible.

Indomethacin can reduce the tubular secretion of methotrexate, which leads to an increase in its toxicity.

With simultaneous use with NSAIDs, the toxicity of cyclosporine increases.

Indomethacin at a dose of 50 mg 3 times a day increases the concentration of lithium in the blood plasma and reduces the clearance of lithium from the body in patients with mental illness.

With the simultaneous use of indomethacin with digoxin, it is possible to increase the concentration of digoxin in the blood plasma and increase the half-life of digoxin.

Analogues of the drug Indomethacin

Structural analogues for the active substance:

• Indobene;
• Indovis EU;
• Indocollier;
• Indomethacin (Movimed);
• Indomethacin 100 Berlin-Chemie;
• Indomethacin 50 Berlin-Chemie;
• Indomethacin Sopharma;
• Indomethacin-Acri;
• Indomethacin-Altfarm;
• Indomethacin-Biosynthesis;
• Indotard;
• Indocide;
• Metindol retard;
• Metindol.

Excipients: lactose monohydrate 41.6 mg, potato starch 10 mg, microcrystalline cellulose 16 mg, 2.5 mg, magnesium stearate 0.9 mg.

The composition of the film shell: cellacephate 2.2 mg, polysorbate-80 0.72 mg, titanium dioxide 1.08 mg.

10 pieces. - blister packs (aluminum/PVC) (1) - cardboard packs.
10 pieces. - blister packs (aluminum/PVC) (2) - cardboard packs.
10 pieces. - blister packs (aluminum/PVC) (3) - cardboard packs.
10 pieces. - blister packs (aluminum/PVC) (4) - cardboard packs.
10 pieces. - blister packs (aluminum/PVC) (5) - cardboard packs.
10 pieces. - cellular contour packings (aluminum/PVC) (6) - packs of cardboard.
10 pieces. - blister packs (aluminum/PVC) (8) - cardboard packs.
10 pieces. - blister packs (aluminum/PVC) (10) - cardboard packs.
30 pcs. - blister packs (aluminum/PVC) (1) - cardboard packs.
30 pcs. - blister packs (aluminum/PVC) (2) - cardboard packs.
30 pcs. - blister packs (aluminum/PVC) (3) - cardboard packs.
30 pcs. - blister packs (aluminum/PVC) (4) - cardboard packs.
30 pcs. - blister packs (aluminum/PVC) (5) - cardboard packs.
30 pcs. - cellular contour packings (aluminum/PVC) (6) - packs of cardboard.
30 pcs. - blister packs (aluminum/PVC) (8) - cardboard packs.
30 pcs. - blister packs (aluminum/PVC) (10) - cardboard packs.
10 pieces. - polymer cans (1) - packs of cardboard.
20 pcs. - polymer cans (1) - packs of cardboard.
30 pcs. - polymer cans (1) - packs of cardboard.
40 pcs. - polymer cans (1) - packs of cardboard.
50 pcs. - polymer cans (1) - packs of cardboard.
60 pcs. - polymer cans (1) - packs of cardboard.
100 pieces. - polymer cans (1) - packs of cardboard.

pharmachologic effect

NSAIDs, a derivative of indoleacetic acid. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is associated with inhibition of the COX enzyme, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.

Suppresses platelet aggregation.

When administered orally and parenterally, it helps to relieve pain, especially joint pain at rest and during movement, reduce morning stiffness and swelling of the joints, and increase range of motion. The anti-inflammatory effect develops by the end of the first week of treatment.

When applied topically, it eliminates pain, reduces swelling and erythema.

When applied externally, it also helps to reduce morning stiffness and increase range of motion.

Pharmacokinetics

After oral administration, indomethacin is rapidly absorbed from the gastrointestinal tract. C max in is achieved after 2 hours. It is metabolized in the liver. It undergoes enterohepatic recirculation. Indomethacin is determined in plasma as an unchanged substance and unbound metabolites - desmethyl, desbenzoyl, desmethyl-desbenzoyl.

T 1 / 2 is about 4.5 hours. Excreted in the urine - 60% in the form of unchanged substance and metabolites, and with feces - 33% mainly in the form of metabolites.

Indications

For systemic use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea. As an aid in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

For local use: prevention of the inflammatory process during surgical interventions for cataracts and in the anterior segment of the eye, inhibition of miosis during surgery.

For external use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and joints.

Contraindications

Hypersensitivity to indomethacin, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, "aspirin triad", hematopoietic disorders, severe liver and / or kidney dysfunction, severe forms of chronic heart failure, arterial hypertension, pancreatitis, III trimester of pregnancy, children under 14 years; for rectal use: proctitis, recent bleeding from the rectum.

Dosage

Set individually, taking into account the severity of the course of the disease. For adults, when taken orally, the initial dose is 25 mg 2-3 times / day. With insufficient severity of the clinical effect, the dose is increased to 50 mg 3 times / day. Dosage forms of prolonged action are used 1-2 times / day. Maximum daily dose: 200 mg.

When the effect is achieved, treatment is continued for 4 weeks at the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg. Taken after meals.

For the treatment of acute conditions or relief of an exacerbation of a chronic process, 60 mg is administered intramuscularly 1-2 times / day. The duration of the / m administration is 7-14 days. Then indomethacin is used orally or rectally, 50-100 mg 2 times / day, while maximum daily dose should not exceed 200 mg. For maintenance treatment, apply rectally at 50-100 mg 1 time / day at night.

For local use in ophthalmology, the dose, frequency and duration of use are determined individually.

Externally applied 2 times / day.

Side effects

From the side digestive system: nausea, anorexia, vomiting, pain and discomfort in the abdomen, constipation or diarrhea, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or from a diverticulum, jaundice, hepatitis.

From the CNS and peripheral nervous system: dizziness, headache, depression, feeling tired; rarely - anxiety, fainting, drowsiness, convulsions, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disturbances, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism.

From the side of the cardiovascular system: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive insufficiency, hematuria.

Allergic reactions: rarely - itching, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylactic reactions, angioedema, dyspnea, bronchial asthma , pulmonary edema.

From the hematopoietic system: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC syndrome.

From the sense organs: rarely - a violation of the clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness.

From the urinary system: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, impaired renal function, renal failure.

From the side of metabolism: rarely - hyperglycemia, glucosuria, hyperkalemia.

Others: rarely - vaginal bleeding, hot flashes, increased sweating, epistaxis, enlargement and tension of the mammary glands, gynecomastia.

Local reactions: at the site of the / m injection in some cases - the formation of an infiltrate, abscess; with rectal use, irritation of the rectal mucosa, tenesmus, exacerbation of chronic colitis are possible.

For external use: itching, redness, rash at the site of application.

drug interaction

With the simultaneous use of indomethacin may reduce the effects of saluretics,; enhance the effects of indirect anticoagulants.

With the simultaneous use of indomethacin and diflunisal, there is a risk of severe bleeding from the gastrointestinal tract.

With simultaneous use with probenecid, an increase in the concentration of indomethacin in the blood plasma is possible.

Indomethacin may decrease tubular secretion, leading to increased toxicity.

With simultaneous use with NSAIDs, the toxicity of cyclosporine increases.

Indomethacin at a dose of 50 mg 3 times / day increases the concentration of lithium in the blood plasma and reduces the clearance of lithium from the body in patients with mental illness.

With the simultaneous use of indomethacin with digoxin, an increase in the concentration of digoxin in the blood plasma and an increase in T 1/2 of digoxin are possible.

special instructions

Use with caution in elderly patients, as well as in diseases of the liver, kidneys, gastrointestinal tract in history, with dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after major surgical interventions, with parkinsonism, epilepsy.

With indications in the anamnesis of allergic reactions to NSAIDs, they are used only in urgent cases.

During the period of treatment, systematic monitoring of the function of the liver and kidneys, the picture of peripheral blood is necessary.

Do not use indomethacin concomitantly with diflunisal.

With the simultaneous use of indomethacin with lithium preparations, the possibility of symptoms of the toxic effects of lithium should be borne in mind.

When applied topically, do not apply to the wound surface of the skin, and avoid contact with the eyes or mucous membranes.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, one should refrain from potentially hazardous activities associated with the need to concentrate and increase the speed of psychomotor reactions.

Pregnancy and lactation

Indomethacin is contraindicated in the third trimester of pregnancy. In the I and II trimesters of pregnancy, as well as during lactation (breastfeeding), the use is not recommended.

Indomethacin is excreted in breast milk in small amounts.

Application in childhood

Contraindicated in children under 14 years of age.

For impaired renal function

Contraindicated in severe renal impairment. Use with caution in kidney disease.

For impaired liver function

Contraindicated in severe liver dysfunction. Use with caution in liver diseases.

Use in the elderly

Use with caution in elderly patients.

Indomethacin tablets - medicine used in the symptomatic treatment of diseases accompanied by pain and fever. Has a large number side effects, therefore it is used for short-term courses.

ATX

Composition and dosage forms

The drug is available in the form of round biconvex tablets coated with an enteric film. Brown color. They are packed in contour cells of 30 pcs. The cardboard box includes 1 blister and instructions. Each tablet contains:

• indomethacin (25 mg);
• potato starch;
• magnesium stearate;
• silica anhydrous;
• talc;
• povidone.

Pharmacological group

pharmachologic effect

The active substance has the following properties:

1. Suppresses the activity of cyclooxygenase, which is involved in the production of prostaglandins, which are mediators of inflammation. The drug prevents the development of pain, an increase in the permeability of the vascular walls and an increase in temperature in the inflammatory focus.
2. Prevents agglutination of platelets.
3. Helps to reduce the intensity of pain syndrome of rheumatic origin. Eliminates morning stiffness and swelling in the joints, increases the mobility of the affected areas of the musculoskeletal system.
4. Eliminates signs of inflammation after injuries and surgical interventions. Reduces the severity of swelling of the surgical wound.

When taken orally, it is rapidly absorbed into the blood. The highest concentration of indomethacin in the blood is found after 120 minutes. Plasma proteins bind 90% of the dose taken. The half-life of indomethacin is 6 hours. transformation active substance takes place in the liver. Most of the indomethacin leaves the body in the urine. The remaining amount is excreted with feces. The drug crosses the blood-brain barrier.

What do indomethacin tablets help with?

The drug is used for:

• inflammation of the joints of a rheumatoid and psoriatic nature;
• chronic juvenile arthritis;
• Reiter's syndrome (chlamydial joint damage);
• Paget's disease;
• ankylosing spondylitis;
• headache and toothache;
• radiculitis and sciatica;
• neuralgic amyotropia;
• intercostal neuralgia;
• recovery after injuries and surgical interventions;
• inflammation of the articular bag and tendons;
• algomenorrhea;
• secondary hyperaldosteronism;
• premature birth (as an anesthetic and antispasmodic);
• inflammatory diseases of the pelvic organs (in gynecology, indomethacin is used for endometritis, adnexitis, salpingoophoritis);
• inflammation of the middle ear;
• infectious diseases of the upper respiratory tract(tonsillitis, pharyngitis, sinusitis);
• febrile syndrome caused by the spread malignant tumors(with the ineffectiveness of paracetamol and ibuprofen);
• chronic prostatitis.

How to take indomethacin tablets

Tablets are taken orally during or after meals. The drug is recommended to drink milk. The initial single dose for adults is 25 mg. Tablets are drunk 3 times a day. With insufficient severity of the anti-inflammatory effect, the daily dose is increased to 150 mg. A single dose should not exceed 75 mg.

The drug about which will be discussed below, belongs to the group of NSAIDs already known to us. Reviews about indomethacin are extremely controversial and polar. We have come across on the forums with harsh criticism of this drug and descriptions of the terrible consequences of taking it. Well, let's get acquainted with the instructions for its use and draw our own conclusions - especially since the list of contraindications is very impressive.

How it works

Let us immediately state that It is not recommended to take this drug without prior medical advice. Indomethacin belongs to the group of NSAIDs and is one of the derivatives of indoleacetic acid. It has antipyretic, anti-inflammatory and analgesic properties. The mechanism of action is based on the inhibition of the so-called COX enzymes and the suppression of the synthesis of prostaglandins, which are formed from arachidonic acid.

The drug also inhibits the synthesis of platelets, relieves pain (especially in the joints and muscle tissues), relieves swelling of the joints and stiffness of movements, promotes an increase in range of motion.

Indications for use

Allocate local and external use of this medicine. Your doctor may prescribe indomethacin if:

• degenerative and inflammatory diseases of the musculoskeletal system (, chronic and, as well as);
• soft tissue lesions of a rheumatic nature;
• complex therapy (for infectious lesions of the ENT organs, prostatitis, neuritis, toothache and headache,).

Local application is possible with:

• surgical interventions (prevention of inflammation);
• inhibition of miosis during surgery.

External use is allowed if you have:

• articular syndrome (gout, rheumatoid arthritis, ankylosing spondylitis,);
• traumatic inflammation.

Release form

The price of the drug varies depending on its form of release. Dragees will cost less, tablets - more expensive. In general, the following forms of indomethacin are common (they are found under various names):

• Eye drops (a typical example is the French Indocollier, it costs about 220 rubles);
• Rectal suppositories (50 and 100 mg each, prices vary from 75 to 205 rubles);
• Tablets (30 and 60 pieces per pack, cost - about 30 rubles);
• Dragees (Bulgarian production, 30 pieces per pack, contain 25 mg of the substance);
• Capsules (Russian, 20 and 30 pieces in 1 package);
• Candles (German and Russian production);
• Ointment (also mainly Bulgarian, contains a 10% concentrate of the substance, weight - 40 grams);

Dosage

Regulated depending on the form of drug use.

• Tablets. The dose is calculated by the doctor taking into account the severity of the disease. An adult is recommended to take 25 mg of indomethacin, divided into 2-3 times a day. In emergency cases, the dose is increased to 50 mg. If the therapeutic effect is achieved after 4 weeks, the dosage is gradually reduced. In no case should you exceed (even with severe ailments) the daily limit of 75 mg. The remedy is used only after meals.
• Rectal suppositories. The drug enters the body through the rectum. Before you enter the suppository, experts advise to empty the intestines. Adults usually take 100 mg per day (1 suppository), or twice 50 mg. In acute gouty attacks, the dose is increased to 200 mg.
• Injections. With exacerbations, the drug is administered intramuscularly, 60 mg (not more than 1-2 times daily). The course of treatment in this case lasts no more than two weeks.

Side effects

• Digestive tract. Abdominal pain, NSAID gastropathy, anorexia, nausea, heartburn, vomiting, liver dysfunction, diarrhea. With prolonged use, there is a possibility of ulceration.
• Nervous system. Dizziness, headache, insomnia, irritability, overexcitability, depression, drowsiness, fatigue, peripheral.
• Sense organs. Diplopia, hearing loss, taste disturbance, tinnitus, corneal clouding, blurred vision, conjunctivitis.
• Heart and blood vessels. Tachyarrhythmia, heart failure, increased blood pressure.
• Urinary system. Proteinuria, renal dysfunction, hematuria, nephrotic syndrome, interstitial nephritis, papillary necrosis.
• Hemostasis. Thrombocytopenia, bleeding (uterine, hemorrhoidal, gingival and gastrointestinal).
• Allergy. , itching, skin rash, urticaria, bronchospasm. There is a low probability of erythema nodosum, and anaphylactic shock.
• Hematopoietic system. , agranulocytosis, autoimmune hemolytic and aplastic anemia.
• Metabolism. Glucosuria and hyperglycemia.

In addition, doctors do not exclude the possibility of hyperkalemia, edematous syndrome, increased sweating and, as well as exacerbation of hemorrhoids, itching and burning in some areas.

Contraindications

We note right away that indomethacin is categorically not recommended for use during pregnancy (the consequences for the development of the fetus are unpredictable) and during lactation. In addition, there are the following contraindications:

• ulceration of the duodenum and stomach;
• gastrointestinal or intracranial bleeding;
• heart failure;
• damage to the optic nerve;
• violation of color vision;
• bronchial asthma;
• liver failure and cirrhosis of the liver;
• hemophilia and other blood diseases;
• hearing loss;
• kidney failure;
• hemorrhoids or proctitis;
• age restrictions (up to 18 years);
• hypersensitivity to NSAIDs, aspirin asthma

special instructions

Treatment is carried out under constant medical supervision. With extreme caution, indomethacin is used by the elderly, as well as by patients who have problems with the liver, kidneys, gastrointestinal tract and cardiovascular system. Also, do not abuse this tool in the postoperative period.

At the slightest hint of an allergic reaction of the body, the use of the drug is stopped. The only exceptions are emergency cases.

It is vitally important that the medical control of the peripheral circulatory system and the functioning of the urinary system during the treatment period. In the case of local therapy, it is forbidden to apply the drug (in the form of an ointment) to damaged areas of the skin (open wounds). Try also to avoid penetration of indomethacin into the eyes and other mucous membranes.

Analogues

We list some analogues of indomethacin that affect human body in a similar way:

• Indovazin (gel, designed for external use);
• Indomethacin Sopharma (ointment sold in tubes of 40 grams and enteric-coated tablets);
• Indocollir (eye drops);
• Indovis EU (tablets in a soluble shell of 25 mg);
• Indomethacin-altfarm (rectal suppositories).

There are plenty of drugs containing the substance in question in pharmacies, but before purchasing them, you cannot do without diagnostics and a comprehensive examination in the clinic.

drug interaction

• other NSAIDs;
• acetylsalicylic acid;
• lithium preparations (symptoms of toxic lithium poisoning may occur).

It would be useful to recall that when intensive care indomethacin (and related drugs) should not drive a car. Also, do not engage in activities that imply a high level of concentration, as your psychomotor reactions will proceed extremely slowly.

An overdose of this NSAID can lead to very sad consequences. You will experience dizziness, disorientation, nausea, convulsions, numbness of the limbs and other unpleasant "bonuses". Remember that in pharmacies the drug is dispensed only by prescription. You can store the substance for no more than 3 years, then it becomes completely unusable and should be disposed of.