Postinor instructions for use. Cross-drug interactions

Postinor: instructions for use and reviews

Postinor is a postcoital oral contraceptive.

Release form and composition

Dosage form - tablets: in the form of a disk, almost white or white, with a chamfer, on one side there is a circular engraving “INOR. "(2 pcs. In blisters, 1 blister in a cardboard box).

Active ingredient: levonorgestrel, 1 tablet - 0.75 mg.

Auxiliary components: colloidal silicon dioxide, magnesium stearate, potato starch, corn starch, talc, lactose monohydrate.

Pharmacological properties

Pharmacodynamics

Levonorgestrel is a synthetic progestogen with a contraceptive effect and a pronounced progestogenic and antiestrogenic effect. When used in recommended doses, it suppresses ovulation and prevents fertilization if intercourse occurs in the pre-ovulation phase characterized by most likely fertilization. It can also lead to changes in the endometrium that prevent implantation. Postinor's effectiveness will be minimal with the implantation that has already occurred.

The probability of preventing pregnancy with the timely administration of the drug is about 85%. The longer the time interval between sexual contact and taking the drug, the less its effectiveness (95% during the first 24 hours, 85% - after 24-48 hours and 58% - after 48-72 hours). Therefore, Postinor should be taken as early as possible (but no later than 3 days after intercourse), if no contraceptive has been used. In therapeutic doses, levonorgestrel does not significantly alter blood clotting factors and does not affect the metabolism of carbohydrates and fats.

Pharmacokinetics

When taken orally, levonorgestrel is rapidly and almost 100% absorbed. After taking 0.75 mg of the drug, its maximum concentration is reached after 1.6 hours and is approximately 14.1 ng / ml. After reaching the maximum value, the concentration of levonorgestrel gradually decreases, and the half-life reaches 26 hours.

Levonorgestrel is excreted in approximately equal amounts in urine and faeces exclusively in the form of metabolites. Its biotransformation corresponds to the metabolic processes of steroids. Levonorgestrel is hydroxylated in the liver, after which its metabolites are excreted as conjugated glucuronides. Metabolites of substances with clinically significant pharmacological activity on this moment unknown.

Levonorgestrel binds to sex hormone binding globulin (SHBG) and plasma albumin. Approximately 1.5% of the administered dose of Postinor is present in the body unchanged, and 65% active substance binds to SHBG. Absolute bioavailability reaches almost 100% of the dose taken.

Indications for use

According to the instructions, Postinor is a drug used for emergency (postcoital) contraception (after unprotected intercourse or sexual contact using an unreliable method of contraception).

Contraindications

Absolute:

• Severe liver failure;
• Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
• Age under 16;
• Pregnancy;
• Hypersensitivity to any of the components included in the Postinor tablets.

Carefully:

• Crohn's disease;
• Jaundice (including history);
• Diseases of the biliary tract and liver;
• Lactation.

Instructions for use of Postinor: method and dosage

Postinor tablets should be taken orally. In total, you need to take 2 tablets within 72 hours after sexual intercourse, with the second tablet 12-16 hours after taking the first.

To achieve the effect, the drug must be taken as soon as possible after intercourse (no later than 72 hours after it).

If you vomit within 3 hours of any tablet dose, you must take an additional tablet.

Side effects

• Transient adverse reactions (do not require drug treatment): often (more than 10% of cases) - lower abdominal pain, fatigue, acyclic spotting (bleeding), nausea; sometimes (less than 10% of cases) - soreness of the mammary glands, headache, dizziness, diarrhea, vomiting, delayed menstruation (in case of a delay of more than 5-7 days, pregnancy must be excluded);
• Allergic reactions: rash, itching, hives, swelling of the face.

Overdose

An increase in severity is considered a sign of Postinor's overdose. side effects... There is no specific antidote. If necessary, symptomatic therapy is prescribed.

special instructions

Postinor is intended solely for emergency contraception and should not be used as a permanent contraceptive method.

It should be borne in mind that this contraceptive does not protect against sexually transmitted diseases.

Postinor should be taken after unprotected intercourse as soon as possible, since over time its effectiveness decreases (%):

• Less than 24 hours - 95%;
• 25-48 hours - 85%;
• 49-72 hours - 58%.

The drug can be used on any day of the menstrual cycle, but if the cycle is irregular, pregnancy should be excluded before taking the contraceptive. Local barrier contraception (such as a cervical cap or condom) should be used before your next menstrual period. Repeated use of Postinor (after the second unprotected intercourse) during one menstrual cycle is not recommended, as the frequency of acyclic bloody discharge or bleeding.

The drug, as a rule, does not affect the course of the menstrual cycle, however, menstruation may be delayed for several days and the appearance of acyclic spotting. If there is a delay of more than 5-7 days or a change in the nature of menstruation (abundant or scanty discharge), pregnancy must be excluded. Lower abdominal pain and fainting may indicate the development of an ectopic pregnancy.

By adolescents under 16 years of age, Postinor can only be used in exceptional cases (for example, after rape) after a mandatory consultation with a gynecologist.

In case of dysfunction digestive system a decrease in the effectiveness of the drug is possible.

The effect of levonorgestrel on reaction rate and the ability to concentrate has not been studied.

Application during pregnancy and lactation

Pregnancy is a strict contraindication to taking Postinor.

The results of relevant studies did not reveal a negative effect on the fetus in women who, when using this emergency contraceptive, still became pregnant.

Levonorgestrel is determined in breast milk. After taking the pills, you must cancel breast-feeding for at least 24 hours.

With impaired renal function

Information on the use of Postinor in patients with renal dysfunction is not provided by the manufacturer.

Drug interactions

Drugs that induce liver enzymes accelerate the metabolism of levonorgestrel.

The following drugs can reduce the effectiveness of Postinor: St. John's wort preparations, tacrolimus, oxcarbazepine, topiramate, nevirapine, tretinoin, lansoprazole, amprecavil, barbiturates, incl. primidone, phenytoin and carbamazepine, tetracycline, ritonavir, rifabutin, ampicillin, griseofulvin, rifampicin.

Levonorgestrel increases plasma concentrations of glucocorticosteroids, reduces the effectiveness of anticoagulants (coumarin derivatives, phenindione) and hypoglycemic drugs. Women who take these funds should consult a doctor before using Postinor.

Levonorgestrel inhibits the metabolism of cyclosporine, thereby increasing the risk of toxicity.

Analogs

Postinor's analogs are: Ginepriston, Zhenale, Escapel, Laktinet, Eskinor-F, Implanon, Charosetta, Mifepriston, Exluton.

Terms and conditions of storage

Keep out of reach of children in compliance with temperature regime from 15 to 25 ºС.

The shelf life is 5 years.

A synthetic drug with a contraceptive effect, pronounced gestagenic and antiestrogenic properties. At the recommended dosage regimen, levonorgestrel suppresses ovulation and fertilization if sexual intercourse occurs in the pre-ovulation phase, when the possibility of fertilization is greatest. It can also cause changes in the endometrium that prevent implantation. The drug is not effective if implantation has already taken place.

Efficiency: with the help of Postinor tablets, pregnancy can be prevented in about 85% of cases. The more time elapsed between intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% - from 24 to 48 hours and 58% - from 48 to 72 hours). Thus, it is recommended to start taking Postinor tablets as soon as possible (but no later than 72 hours) after sexual intercourse, if no protective measures have been applied. At the recommended dose, levonorgestrel has no significant effect on blood clotting factors, fat and carbohydrate metabolism.

Pharmacokinetics

After oral administration of Postinor, the drug is rapidly and almost completely absorbed. Absolute bioavailability is almost 100% of the dose taken. After taking 0.75 mg of levonorgestrel, the C max in serum, equal to 14.1 ng / ml, is reached after 1.6 hours. After reaching C max, the content of levonorgestrel decreases. T 1/2 is about 26 hours.

Levonorgestrel is excreted approximately equally by the kidneys and through the intestines, exclusively in the form of metabolites. The biotransformation of levonorgestrel corresponds to the metabolism of steroids. Levonorgestrel is hydroxylated in the liver, metabolites are excreted in the form of conjugated glucuronides. Pharmacologically active metabolites of levonorgestrel are unknown. Levonorgestrel binds to serum albumin and sex hormone binding globulin (SHBG). Only 1.5% of the total dose is in free form, and 65% is associated with SHBG.

Release form

The tablets are white or off-white, disc-shaped, chamfered, with a circular engraving "INOR." On one side.

Excipients: colloidal silicon dioxide, potato starch, magnesium stearate, talc, corn starch, lactose monohydrate.

2 pcs. - blisters (1) - cardboard packs.

Dosage

The drug is taken orally. You must take 2 tablets in the first 72 hours after unprotected intercourse. The second tablet should be taken 12 hours later (but no later than 16 hours) after taking the first tablet.

To achieve a more reliable effect, both tablets should be taken as soon as possible after unprotected intercourse (no later than 72 hours).

If vomiting occurs within 3 hours after the 1st or 2nd dose of the Postinor tablet, then another Postinor tablet should be taken.

Postinor can be used at any time of the menstrual cycle. In the case of an irregular menstrual cycle, pregnancy must be excluded first.

After taking emergency contraception before your next menstrual period, topical barrier methods (eg, condom, cervical cap) should be used. The use of the drug for repeated unprotected intercourse during one menstrual cycle is not recommended due to an increase in the frequency of acyclic bleeding / bleeding.

Overdose

Strengthening the severity of side effects. There is no specific antidote. Symptomatic therapy is performed.

Interaction

With the simultaneous administration of drugs-inducers of liver enzymes, the metabolism of levonorgestrel is accelerated.

The following drugs may decrease the effectiveness of levonorgestrel: amprecavil, lansoprazole, nevirapine, oxcarbazepine, tacrolimus, topiramate, tretinoin, barbiturates including primidone, phenytoin, and carbamazepine, drugs containing St. rifabutin, griseofulvin. Levonorgestrel reduces the effectiveness of hypoglycemic and anticoagulant (coumarin derivatives, phenindione) drugs. Increases plasma concentrations of GCS. Women taking these drugs should see a doctor.

Medicines containing levonorgestrel may increase the risk of cyclosporine toxicity by inhibiting its metabolism.

Side effects

Allergic reactions: possibly - urticaria, rash, itching, swelling of the face.

Transient side effects that occur with different frequencies and do not require drug therapy: sometimes (1-10%) - vomiting, diarrhea, dizziness, headache, breast tenderness, delayed menstruation (no more than 5-7 days; if menstruation is delayed for more long term, pregnancy must be excluded); often (more than 10%) - nausea, fatigue, lower abdominal pain, acyclic spotting (bleeding).

Indications

Emergency (postcoital) contraception (after unprotected intercourse or unreliability of the contraceptive method used).

Contraindications

• adolescence up to 16 years;
• severe liver failure;
• pregnancy;
• rare hereditary diseases such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
• hypersensitivity to the components of the drug.

With care: liver and biliary tract diseases, jaundice (including history), Crohn's disease, lactation.

Application features

Application during pregnancy and lactation

Postinor is contraindicated for use during pregnancy. If pregnancy occurred when using an emergency method of contraception, then on the basis of the available data, no adverse effect of the drug on the fetus has been identified.

Levonorgestrel is excreted with breast milk... After taking the drug, breastfeeding should be discontinued for 24 hours.

Application for violations of liver function

The drug is prescribed with caution to patients with diseases of the liver and biliary tract, it is contraindicated in severe liver failure.

Application for impaired renal function

Data on the use of the drug in patients with impaired renal function have not been provided.

Application in children

The drug is contraindicated in adolescence under 16 years of age.

special instructions

Postinor should be used exclusively for emergency contraception. Repeated use of Postinor during one menstrual cycle is not recommended.

The effectiveness of Postinor tablets after unprotected intercourse, in which contraceptives were not used, decreases over time:

The drug does not replace the use of permanent methods of contraception. In most cases, Postinor does not affect the nature of the menstrual cycle. However, acyclic bleeding may occur and menstruation may be delayed for several days. If menstruation is delayed by more than 5-7 days and changes in its nature (scanty or profuse discharge) it is necessary to exclude pregnancy. The appearance of pain in the lower abdomen, fainting conditions may indicate an ectopic (ectopic) pregnancy.

In exceptional cases (including rape), adolescents under 16 years of age need to consult a gynecologist to confirm pregnancy.

After emergency contraception, it is recommended to consult a gynecologist to select the most appropriate method of permanent contraception.

Emergency contraception does not protect against sexually transmitted diseases.

In case of violations of the gastrointestinal tract (for example, with Crohn's disease), the effectiveness of the drug may decrease.

Influence on the ability to drive vehicles and use mechanisms

The influence of Postinor on the ability to drive vehicles and mechanisms has not been studied.

Instructions for the medical use of the medicinal product

POSTINOR®

Tradename

Postinor®

International non-proprietary name

Levonorgestrel

Dosage form

Tablets 0.75 mg

One tablet contains

active substance - levonogrestrel 0.75 mg,

excipients: colloidal anhydrous silicon dioxide, potato starch, magnesium stearate, talc, corn starch, lactose monohydrate.

Description

Round tablets, with a flat surface, white or off-white, beveled, marked "INOR" on one side

Pharmacotherapeutic group

Sex hormones and modulators of the reproductive system. Hormonal contraceptives for systemic use. Progestogens. Levonorgestrel

ATX code G03AC03

Pharmacological properties

Pharmacokinetics

When taken orally, levonorgestrel is rapidly and almost completely absorbed. 1.6 hours after taking one Postinor® tablet, the maximum concentration of the drug in the blood serum reaches 14.1 ng / ml. After this, a two-stage decrease in the concentration of the drug occurs, the half-life ranges from 9 to 14.5 hours.

Levonorgestrel is equally excreted in urine and feces exclusively in the form of metabolites. The biotransformation of levonorgestrel corresponds to the metabolism of steroids. Levonorgestrel is hydroxylated in the liver and metabolites are excreted in the form of conjugated glucuronates. Pharmacologically active metabolites of levonorgestrel are unknown. Levonorgestrel binds to serum albumin and sex hormone binding globulin (SHBG). Only 1.5% of the total dose is in free form, and 65% is associated with SHBG. Absolute bioavailability is almost 100% of the entire dose.

About 0.1% of the dose enters the child's body with breast milk.

Pharmacodynamics

Levonorgestrel at the recommended dose prevents ovulation and fertilization if intercourse occurs before ovulation (at this time, the likelihood of fertilization is higher). In addition, changes in the endometrium caused by levonorgestrel prevent the implantation of a fertilized egg. If the implantation process has already begun, then the drug will be ineffective.

Effectiveness: With the help of Postinor® tablets, pregnancy can be prevented in about 85% of cases. The more time elapsed between intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% - from 24 to 48 hours, and 58% - from 48 to 72 hours). Thus, it is recommended to start taking Postinor® tablets as soon as possible (but no later than 72 hours) after intercourse, if no protective measures have been applied. At the recommended dose, levonorgestrel has no significant effect on the coagulation system and on lipid and carbohydrate metabolism.

Indications for use

Emergency contraception to prevent pregnancy (in the first 72 hours after intercourse) in the absence of contraception or insufficient reliability of the method used

Method of administration and dosage

The drug is administered orally. You need to take 2 tablets. To achieve a more reliable effect, the first pill should be taken as soon as possible after intercourse (no later than 72 hours). The second tablet should be taken 12 hours later (but no later than 16 hours) after taking the first tablet.

If vomiting occurs within three hours after taking any pill, then another pill should be taken.

Postinor® tablets can be used on any day of the menstrual cycle, but only if the previous menstruation was normal.

After taking emergency contraception until your next menstrual period, you should use topical barrier contraception (such as a condom). After using Postinor® tablets, continuous use of oral contraceptives is not contraindicated.

Side effects

Very often (> 1/10)

Nausea, pain in the lower abdomen

Non-menstrual bleeding

Fatigue

Often (> 1/100 to<1/10)

Headache, dizziness

Vomiting, diarrhea

Soreness on palpation of the mammary glands

Delayed menstruation by more than 7 days

Irregular bleeding and spotting

The pattern of menstruation may change temporarily, but for most women, the next period comes on time, within 7 days of the expected time. If menstruation is delayed by more than 5 days, the possibility of pregnancy must be excluded.

Contraindications

Hypersensitivity to drug components

Girls before puberty

Patients with rare hereditary diseases of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption syndrome

Drug interactions

With the simultaneous administration of drugs-inducers of liver enzymes, the metabolism of levonorgestrel is accelerated

Reduce the effectiveness of levonorgestrel: barbiturates, including primidone, phenytoin and carbamazepine, drugs containing St. John's wort (Hypericum perforatum), as well as rifampicin, ritonavir, rifabutin, griseofulvin. Women taking these drugs should see a doctor

Medicines containing levonorgestrel may increase the risk of cyclosporine toxicity by inhibiting its metabolism.

special instructions

Contraceptive should only be used in "emergency" situations. The drug does not replace regularly used contraceptives.

Emergency contraception may not always prevent pregnancy.

The effectiveness of Postinor® tablets after intercourse, in which contraceptives were not used, decreases over time:

If there are doubts about the timing of unprotected intercourse, or if unprotected intercourse has occurred more than 72 hours during the same menstrual cycle, then there is a possibility that conception has already occurred. In this regard, the use of Postinor® during repeated sexual intercourse may be ineffective in preventing pregnancy. If the menstrual cycle is delayed by more than 5 days, or if unusual bleeding occurs on the day of the expected menstruation, or if there are other reasons to assume pregnancy, pregnancy must be ruled out.

If pregnancy occurs after the use of Postinor®, the possibility of an ectopic pregnancy must be taken into account. Especially the presence of ectopic pregnancy can be suspected in women who have severe abdominal pain or fainting, as well as with a history of ectopic pregnancy, fallopian tube surgery, or pelvic inflammatory disease.

The effectiveness of Postinor® may be adversely affected by severe forms of malabsorption syndrome (for example, Crohn's disease). Women suffering from such diseases, if necessary, emergency contraception should consult a doctor.

This drug contains lactose monohydrate and should not be used in patients with rare hereditary diseases of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption syndrome.

After taking Postinor®, menstruation usually goes away normally and comes on time. Sometimes your period may start a few days earlier or later. Women should be advised to visit a doctor in order to select and start using one of the methods of regular contraception. If in the next cycle after using Postinor® and regular hormonal contraception, menstruation does not occur, then pregnancy should be excluded.

Repeated use of the drug during one menstrual cycle is not recommended due to the possibility of disruption of the cycle. Postinor® is ineffective as a standard regular method of contraception and can only be used as an emergency measure. Women who are seeking repeated courses of emergency contraception should be advised to use long-term methods of contraception.

The use of emergency contraception is not a substitute for the necessary precautions associated with protection against sexually transmitted diseases.

Pregnancy and lactation

Postinor® tablets should not be used during pregnancy, as this drug cannot terminate an existing pregnancy. According to epidemiological studies, there was no evidence of an adverse effect of progestogens on the fetus (with the accidental use of an emergency method of contraception).

Levonorgestrel passes into breast milk. The potential effect of the drug on the baby can be dramatically reduced if the mother takes both tablets immediately after feeding and refrains from feeding after taking the tablets.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The effect of the drug on the ability to drive or operate machinery has not been studied.

Overdose

There is no evidence of the development of severe adverse effects after taking large doses of an oral contraceptive drug.

Symptoms: nausea, breakthrough bleeding.

Treatment: symptomatic. The drug has no specific antidote.

Release form and packaging

2 tablets are placed in a blister strip of polyvinyl chloride film and aluminum foil.

1 blister pack, together with instructions for medical use in the state and Russian languages, are placed in a cardboard box

Storage conditions

Store at temperatures between 15 ° C and 25 ° C.

Keep out of the reach of children!

Shelf life

Do not use the drug after the expiration date.

Terms of dispensing from pharmacies

On prescription

Name and country of the manufacturing organization

JSC "Gedeon Richter"

1103 Budapest, st. Dömrøy, 19-21, Hungary

Name and country of the owner of the marketing authorization

JSC "Gedeon Richter", Hungary

The address of the organization that accepts claims from consumers on the quality of products on the territory of the Republic of Kazakhstan.

Postinor is a popular drug to prevent unwanted pregnancies. It is a synthetic progestogen with a contraceptive effect, pronounced progestogenic and antiestrogenic properties. Effectiveness: With the help of pills, pregnancy can be prevented in about 85% of cases. The more time elapsed between intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% - from 24 to 48 hours and 58% - from 48 to 72 hours).

Indications for use

Contraceptive pills for emergency prevention of unwanted pregnancy are used for:

• breaking a condom during intercourse;
• dismounting of a condom during intercourse;
• a single skip of taking the contraceptive pill;
• spontaneous prolapse of the intrauterine device;
• unprotected intercourse during suspected ovulation;
• an unsuccessful interrupted act;
• unprotected intercourse;
• rape.

Contraindications for use

Postinor has a number of contraindications for use, these include:

• an allergic reaction to the components contained in Postinor;
• age less than 18 years (also not recommended for women over 40 years of age due to the risk of thrombosis);
• liver failure;
• pregnancy that has already been established;
• an allergic reaction (intolerance) to lactose;
• Crohn's disease;
• cholelithiasis;
• uterine bleeding;
• varicose veins of the lower extremities;
• lactation.

What is dangerous Postinor

The same pills act on each woman individually. That is why, when describing side effects, all these symptoms do not mean that this occurs in every woman when taking the drug. Side effects include:

• Digestive tract disorders (nausea, vomiting, indigestion, stool disorders).
• Pain in the area of ​​the breast.
• Failure of the menstrual cycle (manifested as a delay in menstruation or, on the contrary, earlier onset of menstruation).
• The appearance of bleeding after taking the pills, which is not associated with menstrual bleeding.
• Ectopic pregnancy.
• Violation from the central nervous system, manifests itself in the form of increased fatigue, migraine, dizziness.

Basically, all side effects go away on their own within two to three days, but if you do not feel better after taking the pills and more than four or five days have passed, then you need to urgently consult a doctor.

Description of the drug, instructions for use

The onset of pregnancy depends on the menstrual cycle, or rather on the immediate day of the menstrual cycle. In a healthy woman of reproductive age, ovulation occurs within 12 hours. Let's recall what ovulation is. Ovulation means when a mature egg leaves the ovary, where it begins to move in the fallopian tube towards the sperm, where they meet. If such a meeting occurs, then an embryo begins to form. For the onset of pregnancy, one unprotected sex is sufficient 3 days before ovulation. And after ovulation within one day. After a successful meeting and formation of the embryo, it takes 3-5 days for its implantation.

In order to decide to take emergency hormonal drugs, it is necessary to assess the exact possibility of pregnancy. If you know the exact time of the onset of ovulation, then you cannot get pregnant 2-3 days after the onset of ovulation. Nowadays, the onset of ovulation is quite easy to find out. There are special tests.

Thus, the use of Postinor is necessary within the first days after unprotected intercourse and no later than 3 days after unprotected intercourse.

It must be remembered that the drug is absolutely ineffective if implantation has already taken place. Postinor does not provoke a miscarriage.

Postinor itself is two white tablets, shaped like a disk and engraved INOR

The drug is able to prevent unwanted pregnancy by 85%, but the more time passes after intercourse, the less its effectiveness. For example:

• 90% - taking the drug in the first 24 hours after intercourse;
• 80% - taking the drug from 24 hours to 48 hours after intercourse;
• 50% - taking the drug from 48 hours to 72 hours after intercourse.

The tablets are taken orally. The first pill is drunk no later than 72 hours after unprotected intercourse, and the second pill is used exactly 12 hours after taking the first, no later than 16 hours.

If after taking the pill no more than 3 hours have passed and vomiting has occurred, then it is necessary to urgently take another Postinor pill.

Postinor is used at any time of the day and on any day of the menstrual cycle.

Reapplication of Postinor is strongly discouraged during one menstrual cycle.

Doctors recommend using all emergency contraceptive drugs no more than once every six months. More frequent use can lead to the development of pathologies from the reproductive system. The result can be infertility. As practice shows, a woman who does not use emergency remedies does not disrupt the natural process of the menstrual cycle and has no problems in the future with conception.

Terms of sale, storage and shelf life

The drug must be stored at room temperature not lower than 15 degrees and not higher than 25 degrees, out of the reach of children.

The shelf life of the drug is 5 years.

The drug is dispensed with a doctor's prescription.

How to understand whether Postinor worked

If the menstrual flow came on time: the duration, the volume of the flow has not changed, then the drug has definitely worked. But there are times when you need to urgently consult a doctor, so, for example, you observe:

• excretion of a profuse character;
• the discharge is very scarce;
• delay in menstrual flow for more than 6 days;
• menstrual flow is accompanied by severe pain in the lower abdomen (the pain is aching in nature or cramping);
• the appearance of sharp pain in the lower abdomen.

What is the delay after taking the drug?

Initially, it is necessary to exclude the onset of pregnancy. To do this, you can do a pregnancy test at home. If the test is positive, then you are pregnant. And if negative, then there is no pregnancy. In this case, it is necessary to exclude an ectopic pregnancy. To do this, you must either consult a gynecologist or do an ultrasound examination of the pelvic organs.

If pregnancy is completely excluded, then the delay after taking Postinor (more than 10 days) may be justified:

• inflammatory processes of the pelvic organs (endometritis, adnexitis, vaginitis, colpitis);
• hormonal imbalance;
• the presence (more precisely, the influence of Postinor) endocrine disorders;
• pathology of the urinary system.

When menstruation begins after taking the drug

Usually, the onset of menstruation after taking the drug may not coincide with the expected date. The first discharge can be scanty in nature, which disappear 2-3 days after the onset and can be repeated 2 times within one month. This indicates the correct work of the drug.

But mostly menstrual bleeding comes either on time, or 2-5 days before the expected date. And also with a delay of up to 5-7 days before the expected date.

Is it worth taking Postinor if NPK occurs during menstruation

The menstrual cycle is considered one of the complex physiological processes. If we consider the full phase of the menstrual cycle, then the most favorable conditions for conception are in the middle of the cycle.

That is why it is believed that the probability of getting pregnant during menstrual bleeding is impossible. But, as practice shows, the likelihood of pregnancy during menstruation is still there.

The best conditions for conception are in the middle of the cycle, where female hormones begin to stimulate the production of follicles, eggs. In the remaining phases, the conditions are not favorable for the onset of conception, but it cannot be said unequivocally that pregnancy will not come in other phases.

That is why, it is only your choice - whether or not to drink Postinor after unprotected sexual intercourse during the menstrual cycle.

Overdose

As practice shows, cases of overdose have not been described. Possible only side effects in the form of nausea, vomiting, bleeding.

Interaction

According to the results of the study of the drug, it was revealed that:

• Metabolism is accelerated by simultaneous use with hepatic enzyme inducers.
• Metabolism slows down when used simultaneously with drugs such as: phenytoin, carbamazepine, animal slaughter drugs, ritonavir, rifabutin, griseofulvin.

Bleeding after taking the drug, how to stop them correctly

Postinor is a fairly strong hormonal drug. Many women are interested in whether there should be spotting after taking the drug.

As a result of Postinor's influence on the hormonal background of a woman, some rejection of the epithelium occurs. That is why spotting can be observed and this is considered the norm.

Such discharge is usually brown, rather scarce in volume. They occur after taking the pills on the 3rd, 6th day.

It is worth remembering that if spotting began a week after taking the drug, then this indicates the development of a pathological process. An urgent need to consult a doctor.

Normally, spotting can go on within 3-7 days, but in some cases, this spotting can go on within two weeks. In this case, it is necessary to consult a specialist. You should also pay special attention for an urgent visit to the doctor if:

• there was pain in the lower abdomen;
• discharge has an admixture of pus;
• the appearance of foamy discharge;
• an increase in body temperature not associated with a cold.

How to stop bleeding? This issue is of particular interest to women. In such cases, self-treatment can lead to the development of pathologies and complications. If bloody discharge of an abundant nature lasting more than 8-10 days, then it is necessary to urgently consult a specialist. The doctor is already prescribing therapy.

The nature of the discharge after taking Postinor

Any bleeding can cause great harm to a woman's life and health. Particular attention should be paid if a woman begins to feel:

• weakness;
• a profuse discharge that does not subside;
• dizziness;
• nausea;
• shortness of breath;
• the duration of the discharge is more than 14 days.

special instructions

Application during pregnancy and lactation: Postinor should not be used during pregnancy. This product does not terminate the pregnancy.

During breastfeeding, the use of Postinor is possible. Since it has been proven that levonorgestrel does not mainly pass into breast milk. It is recommended to use both the first and the second tablet immediately after breastfeeding. And skip breastfeeding once after taking the pills. This will significantly reduce the effect of the pills on the development of the child.

Is it possible to get pregnant after taking Postinor

Improper use of Postinor tablets can lead to pregnancy. You must strictly follow the instructions. And remember, the sooner you start taking the drug, the more likely you are to protect yourself from unwanted pregnancy.

Postinor and its analogues

Escapel. Most often, doctors prescribe Escapel as a replacement for Postinor. Also, the main substance, as in Postinor, is levonorgestrel. But it is considered stronger. So its concentration is increased several times. The drug is available in one tablet per pack. It is used once, within three days after unprotected intercourse. All side effects are quite similar. These include:

• weakness;
• nausea;
• vomit;
• headache;
• pain in the area of ​​the mammary glands.

Zhenale... The main component includes mifepristone. It is applied once. Recommended to apply either 2 hours before or after meals. It is recommended to use the drug no later than 72 hours after unprotected intercourse. Side effects are basically the same, they include:

• nausea;
• vomit;
• upset stool;
• migraine;
• dizziness;
• failure of the menstrual cycle;
• intermenstrual bleeding.

Gynepristone... The main component of this drug is mifepristone. It is applied once within 72 hours or 2 hours before or after meals. But there are slightly other side effects, these include:

• hives;
• pathological vaginal discharge;
• pain in the lower abdomen;
• discomfort in the external genital area;
• weakness.

Postinor and alcohol.

If you study the instructions for use of Postinor, then the effect of alcohol while taking the pills is not described there. Since Postinor itself is a rather complex drug and has many side effects. That is why, in order to avoid unwanted complications, it is better to refuse alcohol.

But if you have already taken alcohol, then studies show that alcohol is removed from the blood after 48 hours. There is no time to wait. That is why it is recommended to drink plenty of water (at least 2 liters) before taking the tablets. Plus, drink activated carbon or use any sorbent.

25 assessments, average: 4,96 out of 5

P N011850 / 01 from 05.03.2010.

Tradename

Postinor

International non-proprietary name

Levonorgestrel

Dosage form

Pills

Postinor composition

Each tablet contains:

Active substance: levonorgestrel 0.75 mg.

Excipients: colloidal silicon dioxide, potato starch; magnesium stearate; talc; corn starch; lactose monohydrate.

Description Postinor

White or off-white flat tablets, disc-shaped with bevelling and circular "INOR" engraving on one side.

Pharmacotherapeutic group

Gestagen

ATX code

Pharmacological properties

Pharmacodynamics

Levonorgestrel is a synthetic progestogen with a contraceptive effect, pronounced progestogenic and antiestrogenic properties. At the recommended dosage regimen, levonorgestrel suppresses ovulation and fertilization if sexual intercourse occurs in the pre-ovulation phase, when the possibility of fertilization is greatest. It can also cause changes in the endometrium that prevent implantation. The drug is not effective if implantation has already taken place.

Efficiency: with the help of Postinor tablets, pregnancy can be prevented in about 85% of cases. The more time elapsed between intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% - from 24 to 48 hours, and 58% - from 48 to 72 hours). Thus, it is recommended to start taking Postinor tablets as soon as possible (but no later than 72 hours) after intercourse, if no protective measures have been applied. At the recommended dose, levonorgestrel does not significantly affect blood clotting factors, fat and carbohydrate metabolism.

Pharmacokinetics

When taken orally, levonorgestrel is rapidly and almost completely absorbed. After taking 0.75 mg of levonorgestrel, the maximum serum concentration of 14.1 ng / ml is reached after 1.6 hours. After reaching the maximum concentration level, the levonorgestrel content decreases, and the half-life is about 26 hours.

Levonorgestrel is excreted approximately equally by the kidneys and through the intestines, exclusively in the form of metabolites. The biotransformation of levonorgestrel corresponds to the metabolism of steroids. Levonorgestrel is hydroxylated in the liver and metabolites are excreted in the form of conjugated glucuronides. Pharmacologically active metabolites of levonorgestrel are unknown. Levonorgestrel binds to serum albumin and sex hormone binding globulin (SHBG). Only 1.5% of the total dose is in free form, and 65% is associated with SHBG. Absolute bioavailability is almost 100% of the dose taken.

Indications for use Postinor

Emergency (postcoital) contraception (after unprotected intercourse or unreliability of the contraceptive method used).

Contraindications

Hypersensitivity to any component of the drug, use in adolescents under 16 years of age, severe liver failure, pregnancy.

Patients with rare hereditary diseases such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Carefully

Diseases of the liver or biliary tract, jaundice (including a history), Crohn's disease, lactation.

Pregnancy and lactation

Postinor should not be used during pregnancy. If pregnancy occurred when using an emergency method of contraception, then on the basis of the available data, no adverse effect of the drug on the fetus has been identified. Levonorgestrel passes into breast milk. After taking the drug, breastfeeding should be stopped for 24 hours.

Dosing and Administration Postinor

The drug is administered orally. You must take 2 tablets in the first 72 hours after unprotected intercourse. The second tablet should be taken 12 hours later (but no later than 16 hours) after taking the first tablet.

To achieve a more reliable effect, both tablets should be taken as soon as possible after unprotected intercourse (no later than 72 hours).

If vomiting occurs within three hours after taking 1 or 2 Postinor pills, then you should take another Postinor pill.

Postinor can be used at any time of the menstrual cycle. In the case of an irregular menstrual cycle, pregnancy must be excluded first.

After taking an emergency contraceptive, before the next menstrual period, use

local barrier contraceptive methods (eg, condom, cervical cap). The use of the drug with repeated unprotected intercourse during one menstrual cycle is not recommended due to an increase in the frequency of acyclic bleeding / bleeding.

Side effect

Allergic reactions are possible: urticaria, rash, itching, swelling of the face. Transient side effects occurring with different frequency (often:> 1/100,<1/10, очень часто: >1/10) and not requiring drug therapy: often: vomiting, diarrhea, dizziness, headache, breast tenderness, delayed menstruation (no more than 5-7 days), if menstruation is delayed for a longer period, pregnancy must be excluded. Very common: nausea, fatigue, lower abdominal pain, acyclic spotting (bleeding).

Overdose

Strengthening the severity of side effects. There is no specific antidote. Treatment is symptomatic.

Interaction with other medicinal products

With the simultaneous administration of drugs-inducers of liver enzymes, the metabolism of levonorgestrel is accelerated. The following drugs may decrease the effectiveness of levonorgestrel: amprecavil, lansoprazole, nevirapine, oxcarbazepine, tacrolimus, topiramate, tretinoin, barbiturates including primidone, phenytoin, and carbamazepine; preparations containing St. John's wort (Hypericumperforatum), as well as rifampicin, ritonavir, ampicillin, tetracycline, rifabutin, griseofulvin. Reduces the effectiveness of hypoglycemic and anticoagulant (coumarin derivatives, phenindione) drugs. Increases plasma concentrations of glucocorticosteroids. Women taking these drugs should see a doctor. Medicines containing levonorgestrel may increase the risk of cyclosporine toxicity by inhibiting its metabolism.

special instructions

Postinor should be used exclusively for emergency contraception! Repeated use of Postinor during one menstrual cycle is not recommended! The effectiveness of Postinor tablets after unprotected intercourse, in which contraceptives were not used, decreases over time:

Time between intercourse and reception Efficiency: Postinor tablets:

24 hours or less 95%

25-48h 85%

The drug does not replace the use of permanent methods contraception. In most cases, Postinor does not affect the nature of the menstrual cycle. However, acyclic bleeding may occur and menstruation may be delayed for several days. If menstruation is delayed by more than 5-7 days and a change in its nature (scant or abundant discharge), pregnancy must be excluded. The appearance of pain in the lower abdomen, fainting conditions may indicate an ectopic (ectopic) pregnancy. In exceptional cases (including rape), adolescents under 16 years old need a consultation with a gynecologist to confirm pregnancy. After emergency contraception, it is recommended to consult a gynecologist to select the most appropriate method for permanent contraception. Emergency contraception does not protect against sexually transmitted diseases. In case of dysfunction gastrointestinal tract(for example, in Crohn's disease) the effectiveness of the drug may decrease.

The effect of the drug on the ability to drive a car and working mechanisms