Tablets - 1 tab .: Active substance: ambroxol hydrochloride 30 mg ....
Is the drug "Indomethacin" (tablets). Due to its anti-inflammatory, analgesic and antipyretic action, it is used to treat inflammatory diseases, eliminate pain, reduce swelling and restore joint mobility.
Description of the drug
The main active ingredient of the drug is indomethacin, which is classified as a derivative of indoleacetic acid. The instructions inside the package of the "Indomethacin" medication are described as elements with a protective enteric coating, which allows the active substance to be released in the intestine, bypassing the stomach. The tablets are round, biconvex in shape, covered with a light brown shell on top.
Tablets come in several dosages: 25 mg, 50 mg and 100 mg of indomethacin. Available in 10 or 40 pieces per pack.
All dosage forms
In addition to tablets, there are other forms of the drug "Indomethacin" for oral use, for example capsules with prolonged action with a dosage of 75 mg. For rectal administration, suppositories with a dose of 50 mg are used. For external use, an ointment of 5% and 10% and a gel of 3% are created.
Mechanism of action
Long-term use of the drug "Indomethacin" (tablets) does not exclude adverse reactions associated with sleep disturbance, dizziness, peripheral neuropathy, headache, agitation, irritability, fatigue. They are characterized by corneal opacity, conjunctivitis, hearing impairment, tinnitus, high blood pressure, edema.
In this article, you can read the instructions for using the drug Indomethacin... Reviews of website visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Indomethacin in their practice are presented. A big request to more actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed that may not have been declared by the manufacturer in the annotation. Indomethacin analogs in the presence of available structural analogs. Use for the treatment of inflammation in rheumatology and gynecology in adults, children, as well as during pregnancy and lactation.
Indomethacin is a non-steroidal anti-inflammatory agent derived from indoleacetic acid. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is associated with inhibition of the enzyme COX, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.
Suppresses platelet aggregation.
When administered orally and parenterally, it helps to relieve pain, especially joint pain at rest and during movement, to reduce morning stiffness and swelling of the joints, to increase the range of motion. The anti-inflammatory effect develops by the end of the first week of treatment.
When applied topically, it relieves pain, reduces edema and erythema.
When applied externally, in addition, it helps to reduce morning stiffness, increase the range of motion.
Pharmacokinetics
After oral administration, indomethacin is rapidly absorbed from the gastrointestinal tract. Metabolized in the liver. Undergoes enterohepatic recirculation. It is excreted in the urine - 60% in the form of unchanged substances and metabolites, and with feces - 33% mainly in the form of metabolites.
Indications
For systemic use:
- back pain;
- neuralgia;
- myalgia;
- traumatic inflammation of soft tissues and joints;
- rheumatism;
- diffuse connective tissue diseases;
- dysmenorrhea.
As an adjuvant in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.
For topical use:
- prevention of the inflammatory process during surgical interventions for cataracts and on the anterior segment of the eye;
- inhibition of miosis during surgery.
For external use:
- articular syndrome (including rheumatoid arthritis, arthrosis or osteoarthritis, ankylosing spondylitis, gout);
- back pain;
- neuralgia;
- myalgia;
- traumatic inflammation of soft tissues and joints.
Release forms
Suppositories for rectal administration 50 mg and 100 mg.
Enteric-coated tablets 25 mg.
Capsules 25 mg and 50 mg.
Ointment for external use 10%.
Gel for external use 5%.
Instructions for use and dosage regimen
Set individually, taking into account the severity of the disease. For adults, when taken orally, the initial dose is 25 mg 2-3 times a day. If the clinical effect is insufficient, the dose is increased to 50 mg 3 times a day. Sustained-release dosage forms are used 1-2 times a day. Maximum daily dose: 200 mg.
When the effect is achieved, treatment is continued for 4 weeks at the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg. It is taken after meals.
For the treatment of acute conditions or relief of an exacerbation of a chronic process, 60 mg is administered intramuscularly 1-2 times a day. Duration of intramuscular injection is 7-14 days. Then indomethacin is administered orally or rectally, 50-100 mg 2 times a day, while the maximum daily dose should not exceed 200 mg. For supportive treatment, 50-100 mg rectally are used once a day at night.
For topical use in ophthalmology, the dose, frequency and duration of use are determined individually.
Outwardly used 2 times a day.
Side effect
- nausea, vomiting;
- anorexia;
- pain and discomfort in the abdomen;
- constipation or diarrhea;
- erosive and ulcerative lesions;
- bleeding and perforation of the gastrointestinal tract;
- intestinal strictures;
- stomatitis;
- flatulence;
- bleeding from the sigmoid colon or from a diverticulum;
- dizziness;
- headache;
- depression;
- feeling tired;
- anxiety;
- fainting;
- drowsiness;
- convulsions;
- peripheral neuropathy;
- muscle weakness;
- involuntary muscle movements;
- sleep disorders;
- mental disorders (depersonalization, psychotic episodes);
- paresthesia;
- swelling;
- increased blood pressure;
- tachycardia;
- chest pain;
- arrhythmia;
- arterial hypotension;
- congestive heart failure;
- hives;
- erythema nodosum;
- skin rash;
- hair loss;
- a sharp drop in blood pressure;
- anaphylactic reactions;
- angioneurotic edema;
- pulmonary edema;
- leukopenia;
- dIC syndrome;
- hearing impairment;
- deafness;
- interstitial nephritis;
- impaired renal function;
- hyperglycemia;
- glucosuria;
- vaginal bleeding;
- hot flashes;
- increased sweating;
- nose bleed;
- enlargement and tension of the mammary glands;
- gynecomastia;
- the formation of infiltration, abscess (with local and intramuscular injection);
- itching, redness, rash at the site of application.
Contraindications
- hypersensitivity to indomethacin;
- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- "aspirin triad";
- disorders of hematopoiesis;
- severe liver and / or kidney dysfunction;
- severe forms of chronic heart failure, arterial hypertension, pancreatitis;
- 3rd trimester of pregnancy;
- children up to age 14;
- for rectal use: proctitis, recent bleeding from the rectum.
Application during pregnancy and lactation
Indomethacin is contraindicated in the 3rd trimester of pregnancy. In the 1st and 2nd trimesters of pregnancy, as well as during lactation (breastfeeding), use is not recommended.
Indomethacin in small amounts is excreted in breast milk.
special instructions
It is used with caution in elderly patients, as well as with a history of liver, kidney, gastrointestinal tract diseases, with dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after serious surgical interventions, with parkinsonism, epilepsy.
If there is a history of allergic reactions to NSAIDs, they are used only in urgent cases.
During the treatment period, systematic monitoring of the function of the liver and kidneys, the picture of peripheral blood is necessary.
Indomethacin should not be used concomitantly with diflunisal.
With the simultaneous use of indomethacin with lithium preparations, one should bear in mind the possibility of symptoms of the toxic effect of lithium.
When applied topically, do not apply to the wound surface of the skin, and avoid contact with eyes or mucous membranes.
Influence on the ability to drive vehicles and use mechanisms
During the period of treatment, one should refrain from potentially hazardous activities associated with the need for concentration and increased speed of psychomotor reactions.
Drug interactions
With the simultaneous use of indomethacin, it can reduce the effects of saluretics, beta-blockers; enhance the effects of indirect anticoagulants.
With the simultaneous use of indomethacin and diflunisal, there is a risk of severe bleeding from the gastrointestinal tract.
With simultaneous use with probenecid, an increase in the concentration of indomethacin in the blood plasma is possible.
Indomethacin can reduce the tubular secretion of methotrexate, which leads to increased toxicity.
With simultaneous use with NSAIDs, the toxicity of cyclosporine increases.
Indomethacin in a dose of 50 mg 3 times a day increases the concentration of lithium in the blood plasma and reduces the clearance of lithium from the body in patients with mental illness.
With the simultaneous use of indomethacin with digoxin, an increase in the concentration of digoxin in the blood plasma and an increase in the half-life of digoxin are possible.
Analogues of the drug Indomethacin
Structural analogues for the active substance:
- Indobene;
- Indovis EU;
- Indocollir;
- Indomethacin (Movimed);
- Indomethacin 100 Berlin-Chemie;
- Indomethacin 50 Berlin-Chemie;
- Indomethacin Sopharma;
- Indomethacin-Acri;
- Indomethacin-Altpharm;
- Indomethacin-Biosynthesis;
- Indotard;
- Indocide;
- Metindol retard;
- Metindol.
Excipients: lactose monohydrate 41.6 mg, potato starch 10 mg, microcrystalline cellulose 16 mg, 2.5 mg, magnesium stearate 0.9 mg.
Film casing composition:cellacephate 2.2 mg, polysorbate-80 0.72 mg, titanium dioxide 1.08 mg.
10 pieces. - contour cell packages (aluminum / PVC) (1) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (2) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (3) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (4) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (5) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (6) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (8) - cardboard packs.
10 pieces. - contour cell packages (aluminum / PVC) (10) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (1) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (2) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (3) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (4) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (5) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (6) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (8) - cardboard packs.
30 pcs. - contour cell packages (aluminum / PVC) (10) - cardboard packs.
10 pieces. - polymer cans (1) - cardboard packs.
20 pcs. - polymer cans (1) - cardboard packs.
30 pcs. - polymer cans (1) - cardboard packs.
40 pcs. - polymer cans (1) - cardboard packs.
50 pcs. - polymer cans (1) - cardboard packs.
60 pcs. - polymer cans (1) - cardboard packs.
100 pieces. - polymer cans (1) - cardboard packs.
pharmachologic effect
NSAID, a derivative of indoleacetic acid. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is associated with inhibition of the enzyme COX, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.
Suppresses platelet aggregation.
When administered orally and parenterally, it helps to relieve pain, especially joint pain at rest and during movement, to reduce morning stiffness and swelling of the joints, to increase the range of motion. The anti-inflammatory effect develops by the end of the first week of treatment.
When applied topically, it relieves pain, reduces edema and erythema.
When applied externally, in addition, it helps to reduce morning stiffness, increase the range of motion.
Pharmacokinetics
After oral administration, indomethacin is rapidly absorbed from the gastrointestinal tract. C max is reached after 2 hours. It is metabolized in the liver. Undergoes enterohepatic recirculation. Indomethacin is determined in blood plasma in the form of an unchanged substance and unbound metabolites - desmethyl, desbenzoyl, desmethyl-desbenzoyl.
T 1/2 is about 4.5 hours. It is excreted in the urine - 60% in the form of unchanged substances and metabolites, and with feces - 33%, mainly in the form of metabolites.
Indications
For systemic use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea. As an adjuvant in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.
For local use: prevention of the inflammatory process during surgical interventions for cataracts and on the anterior segment of the eye, inhibition of miosis during surgery.
For external use: joint syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and joints.
Contraindications
Hypersensitivity to indomethacin, erosive and ulcerative lesions of the gastrointestinal tract in the exacerbation phase, "aspirin triad", hematopoiesis disorders, severe liver and / or kidney dysfunction, severe forms of chronic heart failure, arterial hypertension, pancreatitis, III trimester of pregnancy, children under 14 years; for rectal use: proctitis, recent bleeding from the rectum.
Dosage
Set individually, taking into account the severity of the disease. For adults, when taken orally, the initial dose is 25 mg 2-3 times / day. If the clinical effect is insufficient, the dose is increased to 50 mg 3 times / day. Sustained-release dosage forms are used 1-2 times / day. Maximum daily dose: 200 mg.
When the effect is achieved, treatment is continued for 4 weeks at the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg. It is taken after meals.
For the treatment of acute conditions or relief of an exacerbation of a chronic process, 60 mg intramuscularly is administered 1-2 times / day. Duration of intramuscular injection is 7-14 days. Then indomethacin is administered orally or rectally at 50-100 mg 2 times / day, while maximum daily dose should not exceed 200 mg. For supportive treatment, 50-100 mg rectally administered 1 time / day at night.
For topical use in ophthalmology, the dose, frequency and duration of use are determined individually.
Topically applied 2 times / day.
Side effects
From the digestive system: nausea, anorexia, vomiting, pain and discomfort in the abdomen, constipation or diarrhea, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or from the diverticulum, jaundice, hepatitis.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, depression, feeling tired; rarely - anxiety, fainting, drowsiness, seizures, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disturbances, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism.
On the part of the cardiovascular system: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive insufficiency, hematuria.
Allergic reactions: rarely - itching, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylactic reactions, angioedema, bronchial edema, dyspnoea , pulmonary edema.
From the hematopoietic system: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC syndrome.
From the senses: rarely - impaired clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness.
From the urinary system: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, renal impairment, renal failure.
From the side of metabolism: rarely - hyperglycemia, glucosuria, hyperkalemia.
Others: rarely - vaginal bleeding, hot flashes, increased sweating, nosebleeds, enlargement and tension of the mammary glands, gynecomastia.
Local reactions: in the place of intramuscular injection in some cases - the formation of infiltration, abscess; with rectal administration, irritation of the rectal mucosa, tenesmus, exacerbation of chronic colitis are possible.
For external use: itching, redness, rash at the site of application.
Drug interactions
With the simultaneous use of indomethacin can reduce the effects of saluretics; enhance the effects of indirect anticoagulants.
With the simultaneous use of indomethacin and diflunisal, there is a risk of severe bleeding from the gastrointestinal tract.
With simultaneous use with probenecid, an increase in the concentration of indomethacin in the blood plasma is possible.
Indomethacin can reduce tubular secretion, which leads to increased toxicity.
With simultaneous use with NSAIDs, the toxicity of cyclosporine increases.
Indomethacin in a dose of 50 mg 3 times / day increases the concentration of lithium in the blood plasma and reduces the clearance of lithium from the body in patients with mental illness.
With the simultaneous use of indomethacin with digoxin, an increase in the concentration of digoxin in the blood plasma and an increase in T 1/2 of digoxin are possible.
special instructions
It is used with caution in elderly patients, as well as with a history of liver, kidney, gastrointestinal tract diseases, with dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after serious surgical interventions, with parkinsonism, epilepsy.
If there is a history of allergic reactions to NSAIDs, they are used only in urgent cases.
During the treatment period, systematic monitoring of the function of the liver and kidneys, the picture of peripheral blood is necessary.
Indomethacin should not be used concomitantly with diflunisal.
With the simultaneous use of indomethacin with lithium preparations, one should bear in mind the possibility of symptoms of the toxic effect of lithium.
When applied topically, do not apply to the wound surface of the skin, and avoid contact with eyes or mucous membranes.
Influence on the ability to drive vehicles and use mechanisms
During the period of treatment, one should refrain from potentially hazardous activities associated with the need for concentration and increased speed of psychomotor reactions.
Pregnancy and lactation
Indomethacin is contraindicated in the third trimester of pregnancy. In the I and II trimesters of pregnancy, as well as during lactation (breastfeeding), use is not recommended.
Indomethacin in small amounts is excreted in breast milk.
Pediatric use
Contraindicated in children under 14 years of age.
With impaired renal function
Contraindicated in severe renal impairment. Use with caution in kidney disease.
For violations of liver function
Contraindicated in severe liver dysfunction. Use with caution in liver diseases.
Use in the elderly
Use with caution in elderly patients.
Indomethacin tablets are a drug used in the symptomatic treatment of diseases accompanied by pain and fever. It has a large number of side effects, therefore it is used in short courses.
ATX
Composition and dosage forms
The drug is available in the form of round biconvex tablets, coated with a brown enteric film. They are packed in contour cells of 30 pcs. The cardboard box includes 1 blister and instructions. Each tablet contains:
- indomethacin (25 mg);
- potato starch;
- magnesium stearate;
- anhydrous silicon dioxide;
- talc;
- povidone.
Pharmacological group
pharmachologic effect
The active substance has the following properties:
- Suppresses the activity of cyclooxygenase, which is involved in the production of prostaglandins, which are mediators of inflammation. The drug prevents the development of pain syndrome, an increase in the permeability of the vascular walls and an increase in temperature in the inflammatory focus.
- Prevents platelets from sticking together.
- Helps to reduce the intensity of pain syndrome of rheumatic origin. Eliminates morning stiffness and swelling in the joints, increases the mobility of the affected areas of the musculoskeletal system.
- Eliminates signs of inflammation after trauma and surgery. Reduces the severity of surgical wound edema.
When taken orally, it is rapidly absorbed into the bloodstream. The highest concentration of indomethacin in the blood is detected after 120 minutes. Plasma proteins bind 90% of the dose taken. The half-life of indomethacin takes 6 hours. The transformation of the active substance takes place in the liver. Most of the indomethacin is excreted in the urine. The remaining amount is excreted with feces. The drug crosses the blood-brain barrier.
What do Indomethacin tablets help with?
The drug is used for:
- inflammation of the joints of a rheumatoid and psoriatic nature;
- chronic juvenile arthritis;
- reiter's syndrome (chlamydial joint damage);
- paget's disease;
- ankylosing spondylitis;
- headache and toothache;
- radiculitis and sciatica;
- neuralgic amyotropia;
- intercostal neuralgia;
- recovery from injuries and surgical interventions;
- inflammation of the joint capsule and tendons;
- algodismenorrhea;
- secondary hyperaldosteronism;
- premature birth (as an analgesic and antispasmodic);
- inflammatory diseases of the pelvic organs (in gynecology, indomethacin is used for endometritis, adnexitis, salpingo-oophoritis);
- inflammation of the middle ear;
- infectious diseases of the upper respiratory tract (angina, pharyngitis, sinusitis);
- febrile syndrome caused by the spread of malignant tumors (with the ineffectiveness of paracetamol and ibuprofen);
- chronic prostatitis.
How to take Indomethacin tablets
The tablets are taken orally during or after eating. The drug is recommended to be taken with milk. The initial single dose for adults is 25 mg. The tablets are drunk 3 times a day. If the anti-inflammatory effect is insufficient, the daily dose is increased to 150 mg. A single dose should not exceed 75 mg.
The drug, which will be discussed below, belongs to the group of NSAIDs already known to us. Reviews of indomethacin are extremely contradictory and polar. We have come across on forums with harsh criticism of this drug and descriptions of the terrible consequences of taking it. Well, let's get acquainted with the instructions for its use and draw our own conclusions - especially since the list of contraindications is very impressive.
How it works
Let's make a reservation right away that it is not recommended to take this remedy without prior medical advice. Indomethacin belongs to the group of NSAIDs and is one of the derivatives of indoleonic acid. It has antipyretic, anti-inflammatory and analgesic properties. The mechanism of action is based on inhibition of the so-called COX enzymes and suppression of the synthesis of prostaglandins, which are formed from arachidonic acid.
The drug also inhibits platelet synthesis, relieves pain (especially in joints and muscle tissues), relieves joint swelling and stiffness of movements, promotes an increase in range of motion.
Indications for use
There are local and external use of this medication. Your doctor may prescribe indomethacin if:
- degenerative and inflammatory diseases of ODA (, chronic and as well);
- soft tissue lesions of a rheumatic nature;
- complex therapy (for infectious lesions of the ENT organs, prostatitis, neuritis, toothache and headaches,).
Local application is possible with:
- surgical interventions (prevention of inflammation);
- inhibition of miosis during surgery.
External use is allowed if you have:
- articular syndrome (gout, rheumatoid arthritis, ankylosing spondylitis,);
- traumatic inflammation.
Release forms
The price of the drug fluctuates depending on its form of release. Dragee will cost less, tablets - more expensive. In general, the following forms of indomethacin are common (found under various names): 
- Eye drops (a typical example is the French "Indocollir", it costs about 220 rubles);
- Rectal suppositories (50 and 100 mg each, prices vary from 75 to 205 rubles);
- Tablets (30 and 60 pieces per package, cost - about 30 rubles);
- Dragee (Bulgarian production, 30 pieces per package, contain 25 mg of the substance);
- Capsules (Russian, 20 and 30 pieces in 1 package);
- Candles (German and Russian production);
- Ointment (also, mostly Bulgarian, contains a 10% concentrate of the substance, weight - 40 grams);
Dosage
It is regulated depending on the form of drug use.
- Pills. The dose is calculated by the doctor taking into account the severity of the disease. An adult is recommended to take 25 mg of indomethacin, divided into 2-3 times a day. In urgent cases, the dose is increased to 50 mg. If the therapeutic effect is achieved after 4 weeks, the dosage is gradually reduced. In no case should the daily limit of 75 mg be exceeded (even with severe ailments). The remedy is used only after meals.
- Rectal suppositories. The drug enters the body through the rectum. Before introducing a suppository, experts advise to empty the intestines. Adults usually take 100 mg per day (1 suppository), or twice 50 mg. In acute gouty attacks, the dose is increased to 200 mg.
- Injections. In case of exacerbations, the drug is administered intramuscularly, 60 mg (no more than 1-2 times daily). The course of treatment in this case lasts no more than two weeks.
Side effects
- Digestive tract. Abdominal pain, NSAID gastropathy, anorexia, nausea, heartburn, vomiting, liver dysfunction, diarrhea. With prolonged use, ulceration is possible.
- Nervous system. Dizziness, headache, insomnia, irritability, overexcitation, depression, drowsiness, fatigue, peripheral.
- Senses. Diplopia, hearing impairment, taste disturbance, tinnitus, corneal opacity, blurred vision, conjunctivitis.
- Heart and blood vessels. Tachyarrhythmia, heart failure, increased blood pressure.
- Urinary system. Proteinuria, renal dysfunction, hematuria, nephrotic syndrome, interstitial nephritis, papillary necrosis.
- Hemostasis. Thrombocytopenia, bleeding (uterine, hemorrhoidal, gingival and gastrointestinal).
- Allergy. , itching, skin rash, urticaria, bronchospasm. There is a low likelihood of erythema nodosum and anaphylactic shock.
- Hematopoietic system. , agranulocytosis, autoimmune hemolytic and aplastic anemia.
- Metabolism. Glucosuria and hyperglycemia.
In addition, doctors do not exclude the possibility of hyperkalemia, edematous syndrome, increased sweating and, as well as exacerbation of hemorrhoids, itching and burning in certain areas.
Contraindications
Immediately, we note that indomethacin is categorically not recommended for use during pregnancy (the consequences for fetal development are unpredictable) and during lactation. In addition, there are the following contraindications:
- ulceration of the duodenum and stomach;
- gastrointestinal or intracranial bleeding;
- heart failure;
- damage to the optic nerve;
- violation of color vision;
- bronchial asthma;
- liver failure and liver cirrhosis;
- hemophilia and other blood diseases;
- hearing loss;
- renal failure;
- hemorrhoids or proctitis;
- age restrictions (up to 18 years old);
- hypersensitivity to NSAIDs, aspirin asthma
special instructions
Treatment is carried out under constant medical supervision. With extreme caution, indomethacin is used by the elderly, as well as by patients who have problems with the liver, kidneys, gastrointestinal tract and cardiovascular system. Also, do not abuse this remedy in the postoperative period.
At the slightest hint of an allergic reaction of the body, the use of the drug is stopped. The only exceptions are urgent cases.
Medical control of the peripheral circulatory system and the functioning of the urinary system during the treatment period is vital. In the case of local therapy, it is forbidden to apply the drug (in the form of an ointment) to damaged skin areas (open wounds). Also try to avoid penetration of indomethacin into the eyes and other mucous membranes.
Analogs
We list some analogs of indomethacin that affect the human body in a similar way:
- Indovazin (gel created for external use);
- Indomethacin Sopharma (ointment sold in tubes of 40 grams, and enteric-coated tablets);
- Indocollir (eye drops);
- Indovis EC (25 mg soluble tablets);
- Indomethacin-altpharm (rectal suppositories).
There are plenty of drugs containing the substance in question in pharmacies, but before purchasing them, you cannot do without diagnostics and a comprehensive examination in a polyclinic.
Drug interactions
- other NSAIDs;
- acetylsalicylic acid;
- lithium preparations (symptoms of toxic lithium poisoning may occur).
It will be useful to remind that during intensive therapy with indomethacin (and related drugs), you should not drive a car. Also, do not engage in activities that imply a high level of concentration, since your psychomotor reactions will be extremely slow.
An overdose of this NSAID can lead to very sad consequences. You will experience dizziness, disorientation, nausea, convulsions, numbness of the limbs and other unpleasant "bonuses". Remember that in pharmacies, the drug is dispensed exclusively with a doctor's prescription. The substance can be stored for no more than 3 years, then it becomes completely unusable and should be disposed of.
